Thesis Abstract

Abstract
Cancer remains a significant global health challenge, necessitating the development of innovative therapeutic strategies. This thesis focuses on the Development of Novel Drug Delivery Systems for Targeted Cancer Therapy. The research aims to address the limitations of current cancer treatment modalities by designing and evaluating advanced drug delivery systems that can improve the therapeutic efficacy and reduce the side effects associated with conventional chemotherapy. The study begins with an in-depth exploration of the background of cancer therapy, highlighting the challenges faced in achieving effective and targeted drug delivery to cancer cells. The problem statement underscores the need for novel drug delivery systems that can enhance drug accumulation at the tumor site while minimizing systemic toxicity. The objectives of the study are outlined to guide the research process towards the development and evaluation of these innovative drug delivery systems. Methodologically, a comprehensive literature review is conducted to analyze existing drug delivery technologies, mechanisms of targeted drug delivery, and recent advancements in cancer therapy. The research methodology section details the experimental approaches, materials, and techniques employed in designing and characterizing the novel drug delivery systems. Emphasis is placed on the selection of appropriate drug carriers, targeting ligands, and encapsulation techniques to optimize the delivery of anticancer agents. The findings of the study are discussed in detail, highlighting the efficacy and specificity of the developed drug delivery systems in delivering therapeutic payloads to cancer cells. The results demonstrate enhanced drug accumulation in tumor tissues, improved cellular uptake, and potent anticancer activity compared to conventional chemotherapy. Furthermore, the study evaluates the safety profile of the novel drug delivery systems, emphasizing their biocompatibility and reduced off-target effects. In conclusion, the thesis underscores the significance of developing targeted drug delivery systems for improving cancer therapy outcomes. The novel formulations offer promising potential for enhancing the selectivity and efficacy of anticancer agents, paving the way for personalized and precision medicine approaches in oncology. The study contributes valuable insights to the field of drug delivery and cancer therapy, offering new avenues for future research and clinical translation. Keywords Cancer therapy, Drug delivery systems, Targeted therapy, Nanomedicine, Anticancer agents, Precision medicine.

Thesis Overview

The project titled "Development of novel drug delivery systems for targeted cancer therapy" focuses on the critical need to improve cancer treatment efficacy while minimizing side effects through the development of innovative drug delivery systems. Cancer remains a major global health challenge, with traditional chemotherapy often causing significant adverse effects due to non-specific targeting of healthy tissues alongside cancerous cells. Therefore, there is a growing demand for targeted drug delivery systems that can enhance therapeutic outcomes and reduce systemic toxicity. This research project aims to address these challenges by exploring and developing novel drug delivery systems specifically tailored for targeted cancer therapy. The project will involve a comprehensive review of existing literature on drug delivery systems, cancer biology, and targeted therapy to establish a strong theoretical foundation. Subsequently, the research will focus on designing and optimizing novel drug delivery systems that can selectively deliver anti-cancer agents to tumor sites while sparing healthy tissues. The research methodology will encompass a combination of in vitro studies, in vivo experiments, and computational modeling to evaluate the efficacy, safety, and targeting capabilities of the developed drug delivery systems. Various parameters such as drug release kinetics, cellular uptake mechanisms, pharmacokinetics, and biodistribution profiles will be analyzed to assess the performance of the novel delivery systems in preclinical models. Furthermore, the project will emphasize the importance of interdisciplinary collaboration between pharmaceutical scientists, bioengineers, and clinicians to ensure the translation of research findings into clinical applications. By integrating cutting-edge technologies and innovative strategies, this project aims to contribute to the advancement of personalized cancer therapy and improve patient outcomes. In conclusion, the research project on the "Development of novel drug delivery systems for targeted cancer therapy" represents a crucial endeavor in the field of oncology and pharmaceutical sciences. The outcomes of this research have the potential to revolutionize cancer treatment approaches by enhancing drug efficacy, reducing side effects, and ultimately improving the quality of life for cancer patients.