Thesis Abstract

Abstract
Cancer remains a significant challenge in healthcare, with conventional chemotherapy often associated with systemic toxicity and limited efficacy due to poor selectivity for cancer cells. To address these limitations, this thesis presents the development of novel drug delivery systems for targeted cancer therapy. The study aims to explore the design and optimization of drug delivery systems that can enhance the specificity of anticancer agents to tumor cells while minimizing adverse effects on healthy tissues. Chapter One provides a comprehensive introduction to the research topic, highlighting the background of the study, problem statement, objectives, limitations, scope, significance, and structure of the thesis. This chapter also defines key terms essential for understanding the subsequent chapters. Chapter Two consists of a detailed literature review that examines existing drug delivery systems for cancer therapy, including liposomes, nanoparticles, micelles, and polymer-based carriers. The review critically analyzes the advantages and limitations of each system, highlighting the importance of targeting strategies in improving therapeutic outcomes. Chapter Three outlines the research methodology employed in this study, including the selection of materials, formulation techniques, characterization methods, and in vitro/in vivo evaluation of the developed drug delivery systems. The chapter also discusses the ethical considerations and statistical analyses used to interpret the results. In Chapter Four, the findings of the research are elaborately discussed, focusing on the efficacy and safety profiles of the novel drug delivery systems in delivering anticancer drugs to tumor cells. The chapter presents data on drug release kinetics, cellular uptake, cytotoxicity, and pharmacokinetic properties, providing insights into the mechanisms of action and potential clinical applications. Chapter Five serves as the conclusion and summary of the thesis, highlighting the key findings, implications, and future directions for research in the field of targeted cancer therapy. The chapter emphasizes the significance of developing personalized and precision medicine approaches to improve cancer treatment outcomes while minimizing side effects. In conclusion, the "Development of Novel Drug Delivery Systems for Targeted Cancer Therapy" thesis represents a significant contribution to the field of oncology by proposing innovative strategies to enhance the efficacy and selectivity of anticancer treatments. The findings of this study have the potential to advance the development of personalized therapies that can improve patient outcomes and quality of life in cancer patients.

Thesis Overview

The project titled "Development of Novel Drug Delivery Systems for Targeted Cancer Therapy" aims to address the pressing need for more effective and targeted treatment options for cancer patients. Cancer remains a significant global health challenge, with conventional treatment methods often leading to severe side effects and limited efficacy. Therefore, the development of innovative drug delivery systems that can specifically target cancer cells while minimizing harm to healthy tissues holds great promise in revolutionizing cancer therapy. The research will focus on exploring and developing novel drug delivery systems that can enhance the specificity and efficacy of anticancer drugs. By leveraging advancements in nanotechnology, pharmacology, and biotechnology, the project aims to design and optimize drug delivery platforms that can precisely deliver therapeutic agents to cancer cells. This targeted approach seeks to improve treatment outcomes, reduce side effects, and enhance patient quality of life. The project will involve a multidisciplinary approach, drawing on expertise from fields such as pharmaceutical sciences, bioengineering, and oncology. Through a combination of in vitro and in vivo experiments, the research will evaluate the effectiveness and safety of the novel drug delivery systems in preclinical models of cancer. By characterizing the pharmacokinetics, biodistribution, and therapeutic efficacy of these systems, the study aims to provide valuable insights into their potential clinical application. Furthermore, the project will also investigate the mechanisms underlying the targeted delivery of drugs to cancer cells, including cellular uptake pathways, intracellular trafficking, and drug release kinetics. Understanding these processes is crucial for optimizing the design of drug delivery systems and tailoring them to specific types of cancer and patient populations. Overall, the "Development of Novel Drug Delivery Systems for Targeted Cancer Therapy" project represents a significant step towards advancing personalized and precision medicine in the field of oncology. By harnessing the power of innovative drug delivery technologies, this research holds the promise of transforming cancer treatment paradigms and improving patient outcomes.