Thesis Abstract

Abstract
Cancer remains one of the leading causes of mortality worldwide, necessitating the continuous exploration of innovative therapeutic strategies. The development of novel drug delivery systems for targeted cancer therapy has emerged as a promising approach to enhance the efficacy and reduce the side effects of anticancer drugs. This thesis presents a comprehensive investigation into the design, development, and evaluation of advanced drug delivery systems tailored for targeted cancer treatment. The introduction provides a background of the study, outlining the challenges associated with conventional cancer therapy and the rationale for exploring targeted drug delivery systems. The problem statement emphasizes the urgent need for more effective and less toxic treatment modalities for cancer. The objectives of the study are delineated to guide the research towards developing improved drug delivery systems. The limitations and scope of the study are defined to provide clarity on the boundaries and constraints of the research. The significance of the study is underscored, highlighting the potential impact of novel drug delivery systems on improving cancer treatment outcomes. The structure of the thesis is outlined to give an overview of the organization of the research work, while key terminologies are defined to ensure a common understanding of the concepts used throughout the thesis. The literature review delves into ten critical aspects of drug delivery systems for targeted cancer therapy, synthesizing existing knowledge and identifying gaps in the current research landscape. Various types of drug carriers, targeting strategies, and delivery mechanisms are explored to elucidate the diverse approaches to enhancing drug delivery specificity and efficacy in cancer treatment. The research methodology chapter details the experimental procedures and analytical techniques employed in the development and evaluation of novel drug delivery systems. Eight key components, including formulation design, characterization methods, in vitro and in vivo studies, and data analysis, are elaborated upon to provide a comprehensive understanding of the research methodology. The discussion of findings chapter presents a thorough analysis of the experimental results, highlighting the performance, advantages, and limitations of the developed drug delivery systems. The implications of the findings on targeted cancer therapy are critically evaluated, and potential future research directions are suggested to further advance the field. In conclusion, this thesis summarizes the key findings and contributions towards the development of novel drug delivery systems for targeted cancer therapy. The significance of the research outcomes in improving cancer treatment efficacy and reducing adverse effects is emphasized. Overall, this study underscores the importance of innovative drug delivery approaches in advancing precision medicine for cancer therapy, with the ultimate goal of improving patient outcomes and quality of life.

Thesis Overview

The project titled "Development of Novel Drug Delivery Systems for Targeted Cancer Therapy" aims to address the urgent need for more effective and targeted treatment options for cancer patients. Cancer continues to be a leading cause of mortality worldwide, highlighting the critical need for innovative therapeutic approaches. One promising avenue is the development of novel drug delivery systems that can enhance the efficacy and specificity of cancer treatments while minimizing off-target effects and toxicity. The research will focus on designing and optimizing drug delivery systems that can target cancer cells with precision. By developing delivery systems that can selectively deliver therapeutic agents to cancer cells while sparing healthy tissues, the project aims to improve treatment outcomes and quality of life for cancer patients. Various strategies such as nanoparticle-based drug delivery, liposomes, micelles, and other advanced drug delivery technologies will be explored and evaluated for their potential in targeted cancer therapy. Key aspects of the project will include the design and synthesis of novel drug carriers, characterization of their physicochemical properties, evaluation of their drug loading and release profiles, and assessment of their targeting efficiency and therapeutic efficacy in preclinical models of cancer. The research will also investigate the mechanisms underlying the targeted delivery of drugs to cancer cells, including active targeting strategies that exploit specific molecular markers overexpressed on cancer cells. Furthermore, the project will involve interdisciplinary collaborations with experts in pharmaceutical sciences, cancer biology, nanotechnology, and materials science to ensure a comprehensive and multidisciplinary approach to drug delivery system development. By leveraging cutting-edge technologies and innovative research methodologies, the project aims to make significant contributions to the field of targeted cancer therapy and pave the way for the translation of novel drug delivery systems from bench to bedside. Ultimately, the research overview underscores the significance and potential impact of developing novel drug delivery systems for targeted cancer therapy. By harnessing the power of precision medicine and innovative drug delivery technologies, this project seeks to advance the field of oncology and improve clinical outcomes for cancer patients.