Thesis Abstract

Abstract
Cancer remains a significant global health challenge, and the need for innovative treatment strategies is paramount. The development of novel drug delivery systems for targeted cancer therapy has emerged as a promising approach to enhance the efficacy and reduce the side effects of anticancer agents. This thesis aims to investigate the design, development, and evaluation of advanced drug delivery systems tailored for targeted cancer therapy. Chapter One provides the foundation for the research work with an introduction to the topic, background of the study, problem statement, objectives, limitations, scope, significance, structure of the thesis, and definition of key terms. Chapter Two presents a comprehensive literature review covering ten key aspects related to drug delivery systems, targeted cancer therapy, nanotechnology, biomaterials, and current trends in cancer treatment. Chapter Three outlines the research methodology employed in this study, including the selection of materials, synthesis of drug carriers, drug loading techniques, in vitro and in vivo evaluation methods, data analysis, and statistical tools. This chapter also discusses the ethical considerations and safety measures implemented throughout the research process. In Chapter Four, the findings from the experimental investigations are thoroughly discussed, focusing on the design and characterization of novel drug delivery systems, drug release kinetics, cellular uptake studies, cytotoxicity assessments, and the in vivo performance of the developed formulations in animal models. The results are critically analyzed, and the implications of the findings on the field of targeted cancer therapy are highlighted. Finally, Chapter Five presents the conclusion and summary of the thesis, summarizing the key findings, discussing the significance of the research outcomes, and proposing future directions for further research in the field of drug delivery systems for targeted cancer therapy. Overall, this thesis contributes to the advancement of innovative drug delivery approaches that have the potential to revolutionize cancer treatment strategies and improve patient outcomes. Keywords Cancer therapy, Drug delivery systems, Targeted therapy, Nanotechnology, Biomaterials, Drug release kinetics, In vitro evaluation, In vivo studies, Cytotoxicity, Future perspectives.

Thesis Overview

The project titled "Development of Novel Drug Delivery Systems for Targeted Cancer Therapy" aims to address the urgent need for more effective and targeted treatment options for cancer patients. Cancer remains one of the leading causes of mortality worldwide, with conventional chemotherapy often causing severe side effects due to its non-specific nature. Therefore, the development of innovative drug delivery systems that can specifically target cancer cells while minimizing damage to healthy tissues is crucial for improving patient outcomes and quality of life. This research project will focus on designing and testing novel drug delivery systems that can deliver anti-cancer drugs directly to tumor sites, thereby increasing treatment efficacy and reducing systemic toxicity. The development of these targeted drug delivery systems will involve the use of advanced nanotechnology, biomaterials, and molecular targeting strategies to enhance drug delivery efficiency and specificity. The research will begin with a comprehensive literature review to analyze the current state of drug delivery systems for cancer therapy, including their advantages, limitations, and recent advancements. This review will provide a solid foundation for understanding the challenges and opportunities in the field and will guide the design of the novel drug delivery systems in this project. The methodology will involve the synthesis and characterization of drug-loaded nanoparticles or other carrier systems, followed by in vitro and in vivo studies to evaluate their efficacy in targeting cancer cells and inhibiting tumor growth. Various analytical techniques, such as microscopy, spectroscopy, and cell-based assays, will be employed to assess the performance of the drug delivery systems and understand their mechanisms of action. The findings from this research are expected to contribute to the development of more effective and personalized treatment strategies for cancer patients. By improving the targeted delivery of anti-cancer drugs, these novel drug delivery systems have the potential to enhance treatment outcomes, reduce side effects, and overcome drug resistance in cancer therapy. In conclusion, the project "Development of Novel Drug Delivery Systems for Targeted Cancer Therapy" represents an important step towards advancing the field of cancer treatment through the innovation of precision medicine approaches. This research has the potential to revolutionize cancer therapy by offering more efficient and targeted drug delivery systems that can improve patient survival rates and quality of life."