Study of lipid profile in streptozotocin (stz) – induced diabetic rats under nicotinamide coverage treated with ocimum gratissimum (o.g.) and vernonia amygdalina (v.a.) | Blazingprojects Postgraduate Thesis
Home / Microbiology / Study of lipid profile in streptozotocin (stz) – induced diabetic rats under nicotinamide coverage treated with ocimum gratissimum (o.g.) and vernonia amygdalina (v.a.)

Study of lipid profile in streptozotocin (stz) – induced diabetic rats under nicotinamide coverage treated with ocimum gratissimum (o.g.) and vernonia amygdalina (v.a.)

 

Table Of Contents


Chapter ONE

INTRODUCTION

  • 1.1Introduction
  • 1.2Background of Study
  • 1.3Problem Statement
  • 1.4Objective of Study
  • 1.5Limitation of Study
  • 1.6Scope of Study
  • 1.7Significance of Study
  • 1.8Structure of the Research
  • 1.9Definition of Terms

Chapter TWO

LITERATURE REVIEW

  • 2.1Overview of Lipid Profile
  • 2.2Diabetes and Lipid Profile
  • 2.3Streptozotocin (STZ) Induced Diabetes
  • 2.4Nicotinamide Coverage in Diabetes Treatment
  • 2.5Ocimum Gratissimum (O.G.) in Diabetes Management
  • 2.6Vernonia Amygdalina (V.A.) in Diabetes Management
  • 2.7Combined Treatment Approaches in Diabetes
  • 2.8Effects of O.G. and V.A. on Lipid Profile
  • 2.9Studies on Lipid Profile in Animal Models
  • 2.10Gaps in Current Literature on Lipid Profile

Chapter THREE

RESEARCH METHODOLOGY

  • 3.1Research Methodology Overview
  • 3.2Selection of Animal Model
  • 3.3Induction of Diabetes in Rats
  • 3.4Administration of Nicotinamide Coverage
  • 3.5Treatment with O.G. and V.A.
  • 3.6Measurement of Lipid Profile Parameters
  • 3.7Data Collection and Analysis Methods
  • 3.8Statistical Analysis Techniques

Chapter FOUR

DATA PRESENTATION AND ANALYSIS

  • 4.1Lipid Profile Changes in Diabetic Rats
  • 4.2Effects of Nicotinamide Coverage
  • 4.3Impact of O.G. Treatment
  • 4.4Influence of V.A. Treatment
  • 4.5Combined Effects of O.G. and V.A.
  • 4.6Comparison with Control Group
  • 4.7Discussion on Lipid Profile Findings
  • 4.8Implications for Diabetes Management

Chapter FIVE

SUMMARY, CONCLUSION AND RECOMMENDATIONS

  • 5.1Summary of Research Findings
  • 5.2Conclusion and Interpretation
  • 5.3Contributions to Diabetes Research
  • 5.4Recommendations for Future Studies
  • 5.5Practical Applications in Healthcare

Thesis Abstract

The effect of leaf extract of ocimum gratissimium (scent leaf) and vernonia Amygdalina (bitter leaf) under nicotinanmide coverage was studied using albino wistar rat. Acute toxicity of the plant was carried out using (Lorkes method). LD50 was calculated to be 208 mglkg. The main work involved 49 albino wistar rats weighing 150g to 200g. The rats were put in 7 groups of 7 rats each. Rats in group I served as the control and were administered distilled water and feed. Rats in Groups II-VII were administered OG, V.A, DM+NICO, DM+NICO+OG, DM+NICO+VA, DM+NICO+OG+VA respectively for 28 days according to their body weight. Oral administration was used for all the groups. The result obtained showed the mean± SEM P values (P<0.05) was taken as significant. DM + NICO + OG lowered (P<0.05) the VLDL level. DM + NICO + VA lowered (P<0.05) T – CHOL level compared to the control but DM + NICO + VA was seen to raise T-CHOL level. DM + NICO + OG +V.A significantly lowered (P<0.05) the TG level compared to control, O.G and DM + NICO + VA + O.G groups. According to the study, NICO + V.A lowers Lipid profile. O.G increases LDL levels thereby increasing the risk of atherosclerosis and cardiovascular complication.

Thesis Overview

Blazingprojects Mobile App

📚 Over 50,000 Research Thesis
📱 100% Offline: No internet needed
📝 Over 98 Departments
🔍 Thesis-to-Journal Publication
🎓 Undergraduate/Postgraduate Thesis
📥 Instant Whatsapp/Email Delivery

Blazingprojects App

Related Research

Communication and li. 4 min read

A Pragmatic-Narrative Alignment Model for Multilingual Interaction...

The research investigates how speakers manage meaning across languages in multilingual settings by proposing a Pragmatic-Narrative Alignment Model. It aims to e...

BP
Blazingprojects
Read more →
Art and Design. 3 min read

A Framework for Cross-Sensory Narrative in Contemporary Art Design...

A Framework for Cross-Sensory Narrative in Contemporary Art Design is about how artists combine multiple senses—such as sight, sound, touch, and even smell or...

BP
Blazingprojects
Read more →
Applied science. 3 min read

A Multi-Modal Sensor Fusion Framework for Real-Time Hazard Prediction...

This research explores designing and validating a framework that combines data from multiple sensing modalities to predict hazards in real time. The central ide...

BP
Blazingprojects
Read more →
Agriculture and fore. 2 min read

A Resilience-Based Framework for Agroforestry Crop Yield Optimization...

This research explores a resilience-based framework to optimize crop yields in agroforestry systems, integrating trees with crops to enhance productivity, stabi...

BP
Blazingprojects
Read more →
Agricultural science. 2 min read

A Competency-Based Framework for Agricultural Science Education Reform...

The research focuses on designing and validating a competency-based framework to guide agricultural science education reform. It asks how education for future a...

BP
Blazingprojects
Read more →
Adult education. 2 min read

A-Learning Ecosystem for Transformative Adult Education: A Holistic Model...

This research explores how an interconnected digital and human-centered learning environment can promote transformative outcomes in adult education. It asks whe...

BP
Blazingprojects
Read more →
Zoology. 4 min read

A Unified Framework for Animal Behavioral Ecology Networking Theory...

This research explores how animal behavior in natural systems can be understood through a unified networking-based framework that links individual actions, soci...

BP
Blazingprojects
Read more →
Veterinary Medicine. 4 min read

Development of a Framework for Veterinary Antimicrobial Stewardship in Small Animal ...

This research explores how to develop a practical framework for antimicrobial stewardship (AMS) in small animal veterinary practice. In human and animal health,...

BP
Blazingprojects
Read more →
Urban and Regional P. 2 min read

A Resilience-Driven Urban Growth Boundary Framework for Smart Cities...

This research investigates how cities can manage growth and development in a way that is resilient to shocks (like floods, heatwaves, or economic downturns) by ...

BP
Blazingprojects
Read more →
WhatsApp Click here to chat with us