Study of lipid profile in streptozotocin (stz) – induced diabetic rats under nicotinamide coverage treated with ocimum gratissimum (o.g.) and vernonia amygdalina (v.a.) | Blazingprojects Postgraduate Thesis
Home / Microbiology / Study of lipid profile in streptozotocin (stz) – induced diabetic rats under nicotinamide coverage treated with ocimum gratissimum (o.g.) and vernonia amygdalina (v.a.)

Study of lipid profile in streptozotocin (stz) – induced diabetic rats under nicotinamide coverage treated with ocimum gratissimum (o.g.) and vernonia amygdalina (v.a.)

 

Table Of Contents


Chapter ONE

INTRODUCTION

  • 1.1Introduction
  • 1.2Background of Study
  • 1.3Problem Statement
  • 1.4Objective of Study
  • 1.5Limitation of Study
  • 1.6Scope of Study
  • 1.7Significance of Study
  • 1.8Structure of the Research
  • 1.9Definition of Terms

Chapter TWO

LITERATURE REVIEW

  • 2.1Overview of Lipid Profile
  • 2.2Diabetes and Lipid Profile
  • 2.3Streptozotocin (STZ) Induced Diabetes
  • 2.4Nicotinamide Coverage in Diabetes Treatment
  • 2.5Ocimum Gratissimum (O.G.) in Diabetes Management
  • 2.6Vernonia Amygdalina (V.A.) in Diabetes Management
  • 2.7Combined Treatment Approaches in Diabetes
  • 2.8Effects of O.G. and V.A. on Lipid Profile
  • 2.9Studies on Lipid Profile in Animal Models
  • 2.10Gaps in Current Literature on Lipid Profile

Chapter THREE

RESEARCH METHODOLOGY

  • 3.1Research Methodology Overview
  • 3.2Selection of Animal Model
  • 3.3Induction of Diabetes in Rats
  • 3.4Administration of Nicotinamide Coverage
  • 3.5Treatment with O.G. and V.A.
  • 3.6Measurement of Lipid Profile Parameters
  • 3.7Data Collection and Analysis Methods
  • 3.8Statistical Analysis Techniques

Chapter FOUR

DATA PRESENTATION AND ANALYSIS

  • 4.1Lipid Profile Changes in Diabetic Rats
  • 4.2Effects of Nicotinamide Coverage
  • 4.3Impact of O.G. Treatment
  • 4.4Influence of V.A. Treatment
  • 4.5Combined Effects of O.G. and V.A.
  • 4.6Comparison with Control Group
  • 4.7Discussion on Lipid Profile Findings
  • 4.8Implications for Diabetes Management

Chapter FIVE

SUMMARY, CONCLUSION AND RECOMMENDATIONS

  • 5.1Summary of Research Findings
  • 5.2Conclusion and Interpretation
  • 5.3Contributions to Diabetes Research
  • 5.4Recommendations for Future Studies
  • 5.5Practical Applications in Healthcare

Thesis Abstract

The effect of leaf extract of ocimum gratissimium (scent leaf) and vernonia Amygdalina (bitter leaf) under nicotinanmide coverage was studied using albino wistar rat. Acute toxicity of the plant was carried out using (Lorkes method). LD50 was calculated to be 208 mglkg. The main work involved 49 albino wistar rats weighing 150g to 200g. The rats were put in 7 groups of 7 rats each. Rats in group I served as the control and were administered distilled water and feed. Rats in Groups II-VII were administered OG, V.A, DM+NICO, DM+NICO+OG, DM+NICO+VA, DM+NICO+OG+VA respectively for 28 days according to their body weight. Oral administration was used for all the groups. The result obtained showed the mean± SEM P values (P<0.05) was taken as significant. DM + NICO + OG lowered (P<0.05) the VLDL level. DM + NICO + VA lowered (P<0.05) T – CHOL level compared to the control but DM + NICO + VA was seen to raise T-CHOL level. DM + NICO + OG +V.A significantly lowered (P<0.05) the TG level compared to control, O.G and DM + NICO + VA + O.G groups. According to the study, NICO + V.A lowers Lipid profile. O.G increases LDL levels thereby increasing the risk of atherosclerosis and cardiovascular complication.

Thesis Overview

Blazingprojects Mobile App

📚 Over 50,000 Research Thesis
📱 100% Offline: No internet needed
📝 Over 98 Departments
🔍 Thesis-to-Journal Publication
🎓 Undergraduate/Postgraduate Thesis
📥 Instant Whatsapp/Email Delivery

Blazingprojects App

Related Research

Physiotherapy. 3 min read

Developing a Holistic Model for Chronic Low Back Pain Management in Physiotherapy...

This research aims to create a comprehensive and practical model to help physiotherapists better manage patients with chronic low back pain. Chronic low back pa...

BP
Blazingprojects
Read more →
Physiology. 4 min read

A Framework for Integrating Autonomic Nervous System Responses in Cardiovascular Reg...

This research aims to develop a comprehensive framework that explains how the autonomic nervous system (ANS) controls and coordinates cardiovascular functions. ...

BP
Blazingprojects
Read more →
Philosophy. 3 min read

A Model for Ethical Decision-Making in Autonomous Artificial Agents...

This research explores how to help autonomous artificial agents, like robots or self-driving cars, make ethical decisions when facing dilemmas. As these machine...

BP
Blazingprojects
Read more →
Pharmacy. 4 min read

A Conceptual Framework for Enhancing Medication Adherence Through Pharmacist-Patient...

This research focuses on understanding how better communication between pharmacists and patients can improve medication adherence, which is when patients follow...

BP
Blazingprojects
Read more →
Paediatrics. 4 min read

A Framework for Holistic Pediatric Growth and Development Assessment...

This research focuses on creating a comprehensive framework that can be used to assess how children grow and develop in all areas—physical, cognitive, emotion...

BP
Blazingprojects
Read more →
Office technology. 4 min read

A Framework for Integrating Artificial Intelligence into Office Technology Practices...

This research aims to develop a practical framework to effectively integrate artificial intelligence (AI) into office technology practices. In modern workplaces...

BP
Blazingprojects
Read more →
Nursing. 3 min read

Developing a Holistic Framework for Nurse-Patient Relationship Enhancement in Chroni...

This research focuses on creating a comprehensive and practical framework to improve the relationship between nurses and patients who are managing long-term, ch...

BP
Blazingprojects
Read more →
Music. 2 min read

A Framework for Analyzing Emotional Expression in Cross-Cultural Music Performance...

This research explores how emotions are expressed and perceived in music performances that come from different cultural backgrounds. Music is a universal langua...

BP
Blazingprojects
Read more →
Microbiology. 3 min read

A Framework for Predicting Antibiotic Resistance Development in Clinical Bacteria...

This research aims to develop a helpful framework that can predict how bacteria that cause infections in hospitals and clinics become resistant to antibiotics. ...

BP
Blazingprojects
Read more →
WhatsApp Click here to chat with us