Cardio protective activities of n-hexane extract of desmodium velutinum stem on albino wister rat

Thesis Abstract

This study evaluates the cardio protactive effect of N-hexane extract of
Desmodium Velutinum stem on albino wister rat. Rats used in this study
were grouped into four and each group was fed differentely. Rats in group
one, three, and four wre fed with the aid of a syringe without needle with
6ml of the lipoprotein food mixture containing 3.6g of the cowâs brain twice
a day for seven days. Rats on group two was fed with only growerâs mash
and water for seven days; rats in group three was later administered orally
2ml of dissolved vasoprin drug once in a day for 3 days. Rats in group four
were also administered orally 0.5ml of the liquid drug extract of Desmodium
Velutinum stem once a day for 3 days. During these three (3) days, the rats
were given growerâs mash and water. After the feeding period, the rate fed
with the cowâs brain showed a significant increases in the activities of
marker enzymes such as creatine kinase (CK), creatine kinase MB (CKMB),
Aspartatatranseaminase (AST), Alaninetransminase (ALT), and
lactatedehydrogenase. This study shows that N-hexane extract of
Desmodium Velutinum stem posses cardio protective effect on albino wister
rats than the known drug (vasoprin) if only one can increase the dosage of
the extract for a period of time.