Home / Biochemistry / The effect of n-hexane extract of kola nitida bark on liver function test of albino wistar rats fed with high fat

The effect of n-hexane extract of kola nitida bark on liver function test of albino wistar rats fed with high fat

 

Table Of Contents


Chapter ONE

1.1 Introduction
1.2 Background of Study
1.3 Problem Statement
1.4 Objective of Study
1.5 Limitation of Study
1.6 Scope of Study
1.7 Significance of Study
1.8 Structure of the Research
1.9 Definition of Terms

Chapter TWO

2.1 Overview of Liver Function
2.2 High Fat Diet and Liver Function
2.3 Kola Nitida Bark and its Components
2.4 Effects of N-Hexane Extracts on Liver Function
2.5 Previous Studies on Liver Function Tests
2.6 Mechanisms of Liver Function Tests
2.7 Role of Liver Enzymes in Liver Function
2.8 Impact of High-Fat Diet on Liver Enzymes
2.9 Effects of Kola Nitida Bark on Liver Function
2.10 Summary of Literature Review

Chapter THREE

3.1 Research Methodology Overview
3.2 Research Design
3.3 Sampling Techniques
3.4 Data Collection Methods
3.5 Data Analysis Procedures
3.6 Ethical Considerations
3.7 Validity and Reliability Measures
3.8 Statistical Tools Used

Chapter FOUR

4.1 Overview of Research Findings
4.2 Effects of N-Hexane Extract on Liver Enzymes
4.3 Comparison with High-Fat Diet Results
4.4 Impact of Kola Nitida Bark on Liver Function
4.5 Statistical Analysis of Data
4.6 Discussion on the Results
4.7 Implications of Findings
4.8 Recommendations for Future Research

Chapter FIVE

5.1 Summary of Research
5.2 Conclusion
5.3 Contributions to Knowledge
5.4 Practical Implications
5.5 Limitations of the Study
5.6 Recommendations for Practice
5.7 Recommendations for Further Research
5.8 Conclusion Remarks

Thesis Abstract

Kola bark extract have been widely used in tradition medicine for thousand of year, it improves liver functions and provides protection against high fat fed metabolic rats. Present investigations were carried out on the hepatoprotective role of Kola bark extract meal treatment to high fat fed wistar rat. Healthy adult male wistar rats were divided into four groups Group I rats were fed a standard Laboratory diet (groups match) (20g/rat/day), Group II rats were fed a high-fat diet alone (3.6g/rat/day), Group III rats were fed with combined mixture of 70% of high-fat diet with 30% Kola bark meal (9.8g/rat /day), Group/ V rats were fed with high fat diet and was administered with Lipitor (Atovastatin) (10mg/rat/day) . The rats were sacrificed at the end of the experiment (two weeks) period. The high fat fed rat substantially elevated its serum and liver tissue AST, ALT, ALP, bilirubin with decreased in total protein levels. Where as the levels of all parameters significantly restored towards normalization by the kola bark husk meal treatment. The results obtained suggest that the Kola bark meal have potent hepatoprotective action on high fat fed rats. A companion of the performance in both Kola bark meal and Lipitor treatment on high fat fed rat in respect of hepatoprotective role is clearly indicator that the Kola bark meal treatment was more and related to the result of Lipitor as well as to the normal level.



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