Thesis Abstract

Abstract
MicroRNAs (miRNAs) are small non-coding RNA molecules that play crucial roles in post-transcriptional gene regulation. In recent years, there has been a growing interest in understanding the involvement of miRNAs in cancer progression, given their ability to influence various cellular processes. This thesis aims to explore the role of miRNAs in cancer progression, focusing on the underlying mechanisms and the potential therapeutic implications of targeting these molecules. The introduction provides a background of the study, highlighting the importance of miRNAs in cancer biology. The problem statement underscores the gaps in current knowledge regarding specific miRNAs and their role in promoting or inhibiting cancer progression. The objectives of the study are outlined to investigate the mechanisms by which miRNAs influence cancer progression and to explore the therapeutic potential of targeting these molecules. The limitations of the study are acknowledged, including challenges in elucidating the complex interactions between miRNAs and their target genes. The scope of the study is defined, focusing on specific miRNAs implicated in various types of cancer. The significance of the study lies in its potential to uncover novel therapeutic targets for cancer treatment. The literature review chapter synthesizes existing research on miRNAs in cancer progression, covering topics such as the dysregulation of miRNAs in cancer, the role of miRNAs in tumor growth and metastasis, and the potential of miRNAs as diagnostic and prognostic markers in cancer. The research methodology chapter outlines the experimental approaches used to investigate the role of miRNAs in cancer progression. This includes techniques for miRNA profiling, functional studies to validate the effects of specific miRNAs, and bioinformatic analyses to identify miRNA target genes and pathways. The discussion of findings chapter presents the results of the study, including the identification of key miRNAs involved in cancer progression, the elucidation of their mechanisms of action, and the evaluation of potential therapeutic strategies targeting these miRNAs. The implications of these findings for cancer treatment and future research directions are discussed. In conclusion, this thesis sheds light on the role of miRNAs in cancer progression, highlighting their complex regulatory functions and potential as therapeutic targets. By elucidating the mechanisms by which miRNAs influence cancer development, this study contributes to the growing body of knowledge on the molecular basis of cancer and offers insights into novel strategies for cancer therapy.

Thesis Overview

The project titled "Exploring the Role of MicroRNAs in Cancer Progression: Mechanisms and Therapeutic Potential" aims to investigate the intricate involvement of microRNAs in the development and progression of cancer, with a specific focus on elucidating the underlying molecular mechanisms and exploring the therapeutic potential of targeting microRNAs for cancer treatment. Cancer is a complex and heterogeneous disease characterized by uncontrolled cell growth and proliferation. MicroRNAs, small non-coding RNAs, have emerged as key regulators of gene expression and are known to play critical roles in various cellular processes, including cell differentiation, proliferation, and apoptosis. Dysregulation of microRNAs has been implicated in cancer development, progression, and metastasis, making them attractive targets for therapeutic intervention. The research will begin with a comprehensive review of the existing literature on the role of microRNAs in different types of cancer, highlighting their impact on tumorigenesis, tumor growth, and metastasis. This literature review will provide a solid foundation for understanding the current knowledge and gaps in this field. Following the literature review, the research methodology will be outlined, detailing the experimental approaches and techniques that will be employed to investigate the specific mechanisms through which microRNAs contribute to cancer progression. This will include in vitro and in vivo studies to elucidate the functional roles of selected microRNAs in cancer cells and animal models. The project will then delve into the discussion of the findings, analyzing the data obtained from the experimental studies and interpreting the results in the context of existing knowledge. The discussion will aim to uncover novel insights into the regulatory networks controlled by microRNAs in cancer cells and their potential as therapeutic targets. Lastly, the conclusion and summary of the thesis will synthesize the key findings of the research, highlighting the significance of the results in advancing our understanding of the role of microRNAs in cancer progression and their potential applications in cancer therapy. The implications of the research findings for future studies and clinical interventions will also be discussed, emphasizing the importance of further exploring the therapeutic potential of targeting microRNAs in cancer treatment. Overall, this project seeks to contribute to the growing body of knowledge on the molecular mechanisms underlying cancer progression and to explore innovative approaches for developing targeted therapies that leverage the regulatory functions of microRNAs in cancer cells.