Thesis Abstract

Abstract
MicroRNAs (miRNAs) are small non-coding RNAs that play crucial roles in the regulation of gene expression. In cancer, dysregulation of miRNAs has been widely implicated in tumor initiation, progression, and metastasis. This thesis explores the role of miRNAs in cancer progression and the development of novel therapeutic strategies targeting these molecules. The introductory chapter provides an overview of miRNAs, their biogenesis, and functions in gene regulation. The background of the study highlights the significance of miRNAs in cancer biology and the limitations of current therapeutic approaches. The problem statement underscores the need for innovative strategies to target miRNAs for cancer treatment. The objectives of the study are to investigate specific miRNAs implicated in cancer progression and to explore potential therapeutic interventions targeting these molecules. The literature review chapter critically evaluates existing research on miRNAs in cancer, focusing on key miRNAs involved in driving tumor progression. This chapter highlights the complexity of miRNA networks and their impact on cancer phenotypes. Additionally, it discusses current therapeutic approaches targeting miRNAs and their limitations, providing the foundation for the development of novel strategies. The research methodology chapter outlines the experimental approaches employed to investigate the role of miRNAs in cancer progression. Techniques such as miRNA profiling, functional studies, and bioinformatics analysis are utilized to identify key miRNAs and their downstream targets. The chapter also describes in vitro and in vivo models used to assess the efficacy of novel therapeutic strategies. The discussion of findings chapter presents the results of the study, including the identification of specific miRNAs associated with cancer progression and the evaluation of novel therapeutic interventions. The findings shed light on the molecular mechanisms underlying the oncogenic roles of miRNAs and provide insights into the potential therapeutic benefits of targeting these molecules. In conclusion, this thesis highlights the critical role of miRNAs in cancer progression and the development of innovative therapeutic strategies. By elucidating the complex regulatory networks controlled by miRNAs, this study contributes to our understanding of cancer biology and offers new avenues for targeted cancer therapy. The summary emphasizes the significance of miRNA-based approaches in personalized cancer treatment and the potential for improving patient outcomes.

Thesis Overview

The project titled "Exploring the Role of MicroRNAs in Cancer Progression and Development of Novel Therapeutic Strategies" aims to investigate the intricate involvement of microRNAs in cancer progression and to explore the potential of developing innovative therapeutic approaches based on these small non-coding RNA molecules. Cancer is a complex disease characterized by uncontrolled cell growth and proliferation that can lead to metastasis and significant morbidity and mortality. MicroRNAs are small RNA molecules that post-transcriptionally regulate gene expression and play crucial roles in various biological processes, including cancer development and progression. Aberrant expression of microRNAs has been associated with the initiation, progression, and metastasis of various types of cancer, making them attractive targets for cancer therapy. The research will begin with a comprehensive literature review to provide a solid foundation on the current understanding of microRNAs in cancer biology. This review will cover key concepts related to microRNA biogenesis, function, dysregulation in cancer, and their potential as diagnostic and therapeutic targets. The methodology section will outline the experimental approaches and techniques that will be employed to investigate the role of specific microRNAs in cancer progression. This may include in vitro studies using cancer cell lines, bioinformatics analysis of microRNA expression data from patient samples, and potentially in vivo studies using animal models. The findings and discussion section will present and analyze the results obtained from the experiments conducted. This will include the identification of specific microRNAs that are dysregulated in cancer, their downstream targets, and the functional implications of their dysregulation in cancer progression. Furthermore, the discussion will explore the potential of targeting these microRNAs as a novel therapeutic strategy for cancer treatment. The conclusion and summary section will provide a concise overview of the key findings of the research and their implications for future studies and potential clinical applications. This section will also highlight the significance of the research in advancing our understanding of the role of microRNAs in cancer progression and in developing innovative therapeutic strategies for cancer treatment. Overall, this project aims to contribute to the growing body of knowledge on the role of microRNAs in cancer biology and to pave the way for the development of novel therapeutic approaches that target these small RNA molecules for the treatment of cancer.