Thesis Abstract

Abstract
Cancer remains a significant global health challenge, with alterations in gene expression playing a crucial role in its progression. MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression at the post-transcriptional level and have been implicated in various cellular processes, including cancer development and progression. This thesis aims to explore the role of miRNAs in cancer progression and investigate their potential as therapeutic targets. The introduction provides a background of the study, highlighting the importance of understanding the molecular mechanisms underlying cancer progression. The problem statement emphasizes the need to identify novel therapeutic targets to improve cancer treatment outcomes. The objectives of the study include investigating the dysregulation of miRNAs in cancer, elucidating their impact on cancer progression, and exploring their therapeutic potential. The literature review synthesizes existing knowledge on miRNAs and cancer, covering topics such as miRNA biogenesis, their role in cancer development and progression, and their potential as diagnostic and prognostic markers. The research methodology outlines the experimental approaches and techniques employed to study miRNAs in cancer, including cell culture, molecular biology assays, and bioinformatics analyses. The discussion of findings presents the results of the study, highlighting specific miRNAs implicated in different types of cancer and their mechanistic roles in promoting or inhibiting cancer progression. The implications of these findings for cancer diagnosis, prognosis, and therapy are discussed, emphasizing the potential of miRNAs as therapeutic targets in precision medicine approaches. In conclusion, this thesis provides insights into the intricate interplay between miRNAs and cancer progression, highlighting the potential for targeting miRNAs as a novel therapeutic strategy. By elucidating the roles of specific miRNAs in different cancer types, this study contributes to our understanding of the molecular mechanisms driving cancer progression and offers new avenues for personalized cancer treatment. Keywords MicroRNAs, Cancer Progression, Therapeutic Interventions, Precision Medicine, Gene Expression Regulation.

Thesis Overview

The project titled "Exploring the Role of MicroRNAs in Cancer Progression and Potential Therapeutic Interventions" aims to investigate the intricate role of microRNAs in the progression of cancer and explore their potential as targets for therapeutic interventions. Cancer is a complex and heterogeneous disease characterized by uncontrolled cell growth and spread, posing a significant challenge to effective treatment strategies. MicroRNAs, small non-coding RNA molecules, have emerged as key regulators of gene expression and have been implicated in various cellular processes, including tumorigenesis. The research will begin with a comprehensive literature review to establish the current understanding of the involvement of microRNAs in cancer progression. This will include an examination of the mechanisms through which microRNAs influence tumor development, metastasis, and resistance to treatment. The review will also highlight the potential of microRNAs as diagnostic biomarkers and therapeutic targets in various types of cancer. The subsequent research methodology will involve experimental approaches to elucidate the specific roles of selected microRNAs in cancer progression. This will include in vitro and in vivo studies to investigate the effects of manipulating microRNA expression on cancer cell proliferation, migration, invasion, and response to therapy. Advanced molecular and cellular techniques will be employed to analyze the downstream targets and signaling pathways regulated by the identified microRNAs. The findings from these experiments will be presented and discussed in detail in the results and discussion chapter. The research aims to provide new insights into the molecular mechanisms underlying the involvement of microRNAs in cancer progression and to identify potential therapeutic strategies targeting these molecules. The implications of the findings for the development of novel cancer therapies will be thoroughly evaluated, considering the challenges and opportunities in translating basic research into clinical applications. In conclusion, this project seeks to advance our understanding of the role of microRNAs in cancer progression and to explore their therapeutic potential in the context of personalized medicine. By shedding light on the complex interplay between microRNAs and cancer biology, this research has the potential to contribute to the development of innovative and targeted treatment approaches for cancer patients.