Thesis Abstract

Abstract
Cancer remains a major global health concern, with a complex and multifaceted etiology. In recent years, microRNAs (miRNAs) have emerged as key regulators of gene expression, playing crucial roles in various biological processes, including cancer development and progression. This thesis aims to explore the intricate involvement of miRNAs in cancer, focusing on their mechanisms of action, diagnostic potential, and therapeutic implications. Chapter One provides a comprehensive introduction to the topic, presenting the background of the study, the problem statement, research objectives, limitations, scope, significance, structure of the thesis, and key definitions. The chapter sets the stage for understanding the pivotal role of miRNAs in cancer biology. Chapter Two delves into a detailed literature review, examining existing studies on the role of miRNAs in different types of cancer. This chapter discusses the dysregulation of miRNAs in cancer, their impact on cancer hallmarks such as proliferation, apoptosis, invasion, and metastasis, and their potential as biomarkers for cancer diagnosis and prognosis. Chapter Three outlines the research methodology employed in this study, detailing the experimental approaches, sample collection and analysis methods, bioinformatics tools used for miRNA target prediction, and statistical analyses performed to evaluate the data. This chapter provides a transparent overview of the research process. Chapter Four presents a thorough discussion of the findings obtained from the study. The chapter analyzes the expression profiles of specific miRNAs in different cancer types, elucidates their functional roles in cancer progression, and discusses the potential therapeutic strategies targeting miRNAs for cancer treatment. Chapter Five serves as the conclusion and summary of the thesis, highlighting the key discoveries, implications, and future directions in the field of miRNA-based cancer research. This chapter consolidates the research findings and underscores the importance of further investigations to harness the full potential of miRNAs as novel targets in cancer therapy. Overall, this thesis contributes to the expanding knowledge of miRNAs in cancer development and progression, shedding light on their intricate regulatory networks and therapeutic implications. The findings presented herein offer valuable insights into the diagnostic and therapeutic applications of miRNAs in the fight against cancer, paving the way for future research endeavors in this promising field.

Thesis Overview

The project titled "Exploring the Role of MicroRNAs in Cancer Development and Progression" aims to investigate the intricate involvement of microRNAs (miRNAs) in the pathogenesis and progression of cancer. MicroRNAs are small non-coding RNA molecules that play crucial roles in regulating gene expression at the post-transcriptional level. Their dysregulation has been implicated in various diseases, including cancer, where they can act as both oncogenes and tumor suppressors. The research will delve into the specific mechanisms by which miRNAs influence cancer development and progression, focusing on their ability to modulate key signaling pathways, cell cycle regulation, apoptosis, and metastasis. By understanding the complex interplay between miRNAs and cancer-related processes, this study aims to shed light on potential therapeutic targets and biomarkers for cancer diagnosis and treatment. Through a comprehensive literature review and experimental investigations, the project will explore the differential expression of miRNAs in various cancer types, their functional roles in tumorigenesis, and their potential as prognostic indicators. The research methodology will involve bioinformatics analysis, cell culture experiments, and animal models to elucidate the impact of specific miRNAs on cancer biology. The findings of this study are expected to provide valuable insights into the molecular mechanisms underlying cancer development and progression, with a particular focus on the regulatory roles of miRNAs. By unraveling the complex networks through which miRNAs exert their effects on cancer cells, this research seeks to contribute to the growing body of knowledge in cancer biology and potentially pave the way for the development of novel therapeutic strategies targeting miRNAs. Overall, this project represents a significant contribution to the field of cancer research by elucidating the critical role of miRNAs in driving tumorigenesis and metastasis. By unraveling the intricate interactions between miRNAs and cancer-related processes, this study aims to advance our understanding of cancer biology and potentially identify new avenues for precision medicine approaches in cancer treatment.