Thesis Abstract

Abstract
Cancer remains a significant global health challenge, with a complex etiology involving genetic and epigenetic alterations. This thesis explores the role of epigenetics in cancer development and its potential therapeutic implications. The study delves into the intricate molecular mechanisms underlying epigenetic modifications, such as DNA methylation, histone modifications, and non-coding RNAs, that contribute to cancer initiation and progression. Through an extensive literature review, ten key aspects of epigenetic involvement in cancer are elucidated, highlighting the critical impact of epigenetic dysregulation on oncogenic pathways and tumor suppressor genes. The research methodology section outlines the approach taken to investigate epigenetic changes in various cancer types, including experimental techniques such as next-generation sequencing, chromatin immunoprecipitation assays, and bioinformatics analysis. The findings from these studies are comprehensively discussed in chapter four, revealing the specific epigenetic alterations associated with different cancer types and their potential as therapeutic targets. The significance of this study lies in its potential to advance our understanding of the epigenetic landscape in cancer and identify novel therapeutic strategies aimed at reversing aberrant epigenetic modifications. The limitations and scope of the study are also addressed, acknowledging the challenges inherent in studying dynamic epigenetic changes in cancer heterogeneity. In conclusion, this thesis underscores the pivotal role of epigenetics in cancer development and progression, emphasizing the promising therapeutic avenues that target epigenetic alterations for precision medicine approaches. By shedding light on the complex interplay between epigenetic modifications and cancer pathogenesis, this research contributes to the growing body of knowledge aimed at improving cancer diagnosis and treatment outcomes. Keywords Epigenetics, Cancer, DNA Methylation, Histone Modifications, Non-coding RNAs, Therapeutic Targets, Precision Medicine.

Thesis Overview

The project titled "Exploring the role of epigenetics in cancer development and potential therapeutic implications" focuses on investigating the intricate relationship between epigenetics and cancer progression, with a specific emphasis on exploring the potential therapeutic interventions that could arise from a deeper understanding of this relationship. Epigenetics refers to the modifications in gene expression that occur without alterations in the underlying DNA sequence, playing a crucial role in various biological processes, including cancer development. The research aims to delve into the underlying mechanisms through which epigenetic modifications contribute to the initiation and progression of cancer. By examining the changes in gene expression patterns mediated by epigenetic mechanisms, the study seeks to elucidate how these alterations drive the uncontrolled cell growth and proliferation characteristic of cancer cells. Understanding the epigenetic landscape of cancer cells is essential for identifying novel therapeutic targets and developing more effective treatment strategies. Furthermore, the project seeks to explore the potential therapeutic implications of targeting epigenetic modifications in cancer treatment. Epigenetic-based therapies have shown promising results in preclinical and clinical studies, offering new avenues for personalized and precision medicine approaches in cancer treatment. By investigating the efficacy and safety of epigenetic-targeted therapies, the research aims to contribute to the growing body of knowledge on innovative cancer treatment modalities. Moreover, the project aims to highlight the importance of considering the heterogeneity of epigenetic profiles within different cancer types and individual patients. By examining the diverse epigenetic alterations present in various cancer subtypes, the study aims to provide insights into the development of personalized treatment strategies tailored to the unique epigenetic signatures of individual patients. This personalized approach holds the potential to enhance treatment outcomes and reduce adverse effects associated with conventional cancer therapies. In conclusion, the research overview underscores the significance of exploring the role of epigenetics in cancer development and the potential therapeutic implications that stem from this exploration. By shedding light on the complex interplay between epigenetic modifications and cancer progression, the project aims to contribute to the advancement of precision oncology and the development of innovative therapeutic interventions for improving cancer patient outcomes.