Thesis Abstract

**Thesis Abstract
** MicroRNAs (miRNAs) have emerged as critical regulators of gene expression and play pivotal roles in various cellular processes, including cancer progression. This thesis investigates the involvement of miRNAs in cancer progression and explores their potential implications for therapeutic targeting. The study aims to provide insights into the mechanisms by which miRNAs contribute to cancer development and progression, with a focus on their potential as therapeutic targets for cancer treatment. The research begins with a comprehensive review of the literature on miRNAs and their roles in cancer, highlighting the significance of these small non-coding RNAs in regulating gene expression and influencing tumorigenesis. The literature review encompasses ten key areas, including the biogenesis of miRNAs, their functions in cancer cells, and the implications of dysregulated miRNA expression in cancer progression. Following the literature review, the research methodology section outlines the experimental approaches employed to investigate the role of specific miRNAs in cancer progression. This section includes details on sample collection, miRNA profiling techniques, cell culture experiments, and bioinformatics analysis to identify potential miRNA targets and pathways involved in cancer development. The discussion of findings presents the results of the study, highlighting the differential expression patterns of specific miRNAs in cancer cells compared to normal cells. The findings elucidate the potential mechanisms by which these dysregulated miRNAs contribute to cancer progression, including their effects on cell proliferation, migration, and invasion. The discussion also explores the therapeutic implications of targeting these miRNAs for cancer treatment, including the development of miRNA-based therapeutics and the potential for personalized medicine approaches. In conclusion, this thesis provides valuable insights into the role of miRNAs in cancer progression and their potential as therapeutic targets. The findings contribute to our understanding of the complex interplay between miRNAs and cancer development, offering new opportunities for developing innovative treatment strategies for cancer patients. This research underscores the significance of miRNAs as key players in cancer biology and highlights the importance of further exploring their therapeutic potential in the fight against cancer. **(Word Count 239 words)**

Thesis Overview

The research project titled "Exploring the Role of microRNAs in Cancer Progression: Implications for Therapeutic Targeting" aims to investigate the intricate involvement of microRNAs in cancer progression and explore the potential therapeutic implications of targeting these small non-coding RNA molecules. Cancer is a complex and heterogeneous disease characterized by uncontrolled cell growth and proliferation. MicroRNAs, as key regulators of gene expression, have emerged as critical players in cancer development and progression. The research will begin with a comprehensive literature review to provide a detailed background on microRNAs, their functions, and their dysregulation in cancer. This review will highlight the current understanding of how microRNAs contribute to various aspects of cancer biology, including tumor initiation, metastasis, and resistance to therapy. Following the literature review, the research methodology will be outlined, detailing the experimental approaches and techniques that will be employed to investigate the specific roles of microRNAs in cancer progression. This will include the selection of cell lines or animal models, the isolation and profiling of microRNAs, and the functional studies to elucidate their effects on cancer cell behavior. The subsequent chapter will present the findings of the research, discussing the specific microRNAs identified as critical players in driving cancer progression. The results will delve into the molecular mechanisms through which these microRNAs exert their effects on key signaling pathways involved in cancer development and metastasis. Moreover, the potential of targeting these microRNAs for therapeutic intervention will be explored, including the use of novel delivery systems and gene editing technologies. In the conclusion and summary chapter, the key findings of the research will be synthesized, highlighting the significance of understanding the roles of microRNAs in cancer progression and the implications for developing targeted therapeutic strategies. The limitations of the study and areas for future research will also be discussed, emphasizing the need for further investigation to translate these discoveries into clinical applications. Overall, this research project aims to advance our understanding of the complex interplay between microRNAs and cancer progression, providing insights that could ultimately lead to the development of innovative therapeutic approaches for combating this devastating disease.