Thesis Abstract

Abstract
Cancer, a complex and multifactorial disease, continues to be a major global health challenge. Understanding the molecular mechanisms underlying cancer progression and treatment response is crucial for developing effective therapeutic strategies. In recent years, microRNAs (miRNAs) have emerged as key regulators of gene expression and have been implicated in various aspects of cancer biology. This thesis aims to explore the role of miRNAs in cancer progression and treatment response, with a specific focus on their potential as diagnostic biomarkers and therapeutic targets. Chapter one provides an introduction to the study, presenting the background of the research, the problem statement, objectives, limitations, scope, significance, structure of the thesis, and definitions of key terms. Chapter two presents a comprehensive literature review covering ten key aspects related to miRNAs in cancer, including their biogenesis, functions, dysregulation in cancer, and implications for therapy. Chapter three outlines the research methodology employed in this study, detailing the research design, sample collection and processing, miRNA profiling techniques, data analysis methods, and statistical approaches. This chapter also discusses ethical considerations and potential limitations of the methodology. In chapter four, the findings of the study are discussed in detail. This includes the identification of specific miRNAs associated with cancer progression and treatment response, their molecular mechanisms of action, and their potential clinical implications. The results are interpreted in the context of existing literature and provide insights into the role of miRNAs as promising targets for cancer therapy. Chapter five presents the conclusion and summary of the thesis, highlighting the key findings, implications for future research, and potential clinical applications. The study contributes to the growing body of knowledge on the role of miRNAs in cancer and underscores their significance as diagnostic and therapeutic tools in the fight against this devastating disease. In conclusion, this thesis sheds light on the intricate interplay between miRNAs, cancer progression, and treatment response, providing valuable insights that may inform the development of novel therapeutic strategies and personalized medicine approaches for cancer patients.

Thesis Overview

The project titled "Exploring the Role of MicroRNAs in Cancer Progression and Treatment Response" aims to investigate the intricate involvement of MicroRNAs (miRNAs) in the progression of cancer and their potential impact on treatment response. MicroRNAs are small non-coding RNA molecules that play crucial roles in regulating gene expression post-transcriptionally. In cancer, dysregulation of miRNAs has been implicated in various aspects of tumorigenesis, metastasis, and resistance to therapy. The research will delve into the current understanding of miRNAs in cancer biology, focusing on how these molecules influence key processes such as cell proliferation, apoptosis, and epithelial-to-mesenchymal transition (EMT). By exploring the specific miRNAs involved in different types of cancer and their target genes, the project aims to elucidate the complex mechanisms through which miRNAs contribute to cancer progression. Furthermore, the study will investigate the potential of miRNAs as biomarkers for cancer diagnosis, prognosis, and prediction of treatment response. By analyzing the expression profiles of miRNAs in cancer patients before and after treatment, the project seeks to identify potential biomarkers that could help tailor personalized treatment strategies and improve patient outcomes. Overall, this research project will provide valuable insights into the role of miRNAs in cancer progression and treatment response, shedding light on novel therapeutic targets and diagnostic tools for combating this complex and heterogeneous disease.