Thesis Abstract

Abstract
MicroRNAs (miRNAs) are small non-coding RNA molecules that play crucial roles in the regulation of gene expression and have been implicated in various biological processes, including cancer development and progression. This thesis aimed to explore the role of miRNAs in cancer development and progression by investigating their dysregulation in cancer cells and their potential as diagnostic and therapeutic targets. Chapter One provides an introduction to the study, presenting the background of the research, the problem statement, objectives, limitations, scope, significance, structure of the thesis, and definitions of key terms. The literature review in Chapter Two delves into ten key studies highlighting the involvement of miRNAs in cancer progression, emphasizing their diagnostic and therapeutic potential. Chapter Three outlines the research methodology, including sample collection, miRNA profiling techniques, data analysis methods, and statistical approaches. The findings of the study are extensively discussed in Chapter Four, where the dysregulated miRNAs in various cancer types are identified, and their functional roles in cancer development and progression are elucidated. The potential of miRNAs as diagnostic biomarkers and therapeutic targets is also explored. In conclusion, Chapter Five summarizes the key findings of the study, highlighting the significance of miRNAs in cancer research and their potential clinical applications. The research underscores the importance of understanding the intricate roles of miRNAs in cancer biology for the development of novel diagnostic tools and targeted therapies. This thesis contributes to the growing body of knowledge on miRNAs in cancer and provides a foundation for further research in this field.

Thesis Overview

The project titled "Exploring the Role of MicroRNAs in Cancer Development and Progression" embarks on a comprehensive investigation into the intricate involvement of microRNAs in the processes of cancer development and progression. MicroRNAs are small non-coding RNA molecules that play crucial roles in gene regulation, influencing various cellular functions. In recent years, an increasing body of research has highlighted the significance of microRNAs in cancer biology, demonstrating their potential as both diagnostic markers and therapeutic targets. This research aims to delve into the specific mechanisms through which microRNAs contribute to the initiation, progression, and metastasis of cancer. By elucidating the intricate interplay between microRNAs and the regulatory networks governing cancer cell behavior, this study seeks to enhance our understanding of the molecular underpinnings of cancer pathogenesis. The project will involve a multi-faceted approach, incorporating both in vitro and in vivo experimental techniques to investigate the expression profiles and functional roles of key microRNAs in different types of cancer. By analyzing data from patient samples and cell culture models, the research aims to identify novel microRNA biomarkers associated with specific stages of cancer development and progression. Furthermore, the study will explore the therapeutic potential of targeting dysregulated microRNAs in cancer treatment. By modulating the expression levels of specific microRNAs using synthetic oligonucleotides or gene editing tools, the research aims to assess the impact on tumor growth, metastasis, and drug resistance, providing insights into the feasibility of microRNA-based therapies for cancer patients. Overall, this project represents a comprehensive exploration of the complex interplay between microRNAs and cancer biology, with the ultimate goal of advancing our knowledge of cancer pathogenesis and identifying novel therapeutic strategies to combat this devastating disease.