Thesis Abstract

Abstract
Cancer is a complex and multifaceted disease that continues to be a significant public health challenge worldwide. Despite advancements in treatment modalities, the development of resistance to therapy remains a major obstacle in effectively managing cancer. MicroRNAs (miRNAs) have emerged as critical regulators of gene expression and have been implicated in various cellular processes, including cancer progression and treatment resistance. This thesis aims to explore the role of miRNAs in cancer progression and treatment resistance, with a focus on understanding the underlying mechanisms and potential therapeutic implications. Chapter One provides an introduction to the research topic, including background information on cancer, the significance of miRNAs in cancer biology, and the problem statement related to treatment resistance. The objectives, limitations, and scope of the study are outlined, along with the significance of the research and the structure of the thesis. Additionally, key terminologies related to miRNAs and cancer are defined to provide a comprehensive understanding of the subsequent chapters. Chapter Two presents a comprehensive literature review that examines existing research on miRNAs in cancer progression and treatment resistance. Ten key areas are explored, including the molecular mechanisms of miRNA dysregulation in cancer, the role of specific miRNAs in different cancer types, and the impact of miRNAs on treatment response and resistance mechanisms. Chapter Three details the research methodology employed in this study, outlining the experimental approach, data collection methods, and analysis techniques. Eight key components of the methodology are discussed, including cell culture techniques, miRNA profiling methods, bioinformatic analyses, and statistical approaches used to interpret the data. Chapter Four presents a detailed discussion of the findings obtained from the study, focusing on the role of specific miRNAs in cancer progression and treatment resistance. The results are analyzed in the context of existing literature and implications for future research and clinical applications are discussed. Chapter Five offers a conclusion and summary of the thesis, highlighting the key findings, implications, and contributions to the field of cancer research. The limitations of the study are acknowledged, and recommendations for future research directions are provided to further advance our understanding of the role of miRNAs in cancer biology and therapy. In conclusion, this thesis sheds light on the intricate interplay between miRNAs, cancer progression, and treatment resistance, providing valuable insights into potential therapeutic targets and strategies for improving cancer management. The findings presented in this study contribute to the growing body of knowledge on miRNAs in cancer biology and hold promise for the development of novel therapeutic approaches to combat treatment resistance in cancer patients.

Thesis Overview

The project titled "Exploring the Role of MicroRNAs in Cancer Progression and Treatment Resistance" aims to investigate the intricate involvement of microRNAs in the progression of cancer and the development of treatment resistance. MicroRNAs are small non-coding RNA molecules that play crucial roles in regulating gene expression and are increasingly recognized for their impact on cancer pathogenesis. Understanding how these tiny molecules influence cancer progression and treatment outcomes is essential for developing more effective therapeutic strategies. The research will delve into the molecular mechanisms through which specific microRNAs contribute to the initiation, progression, and metastasis of various types of cancer. By analyzing the dysregulation of microRNAs in cancer cells and their interaction with key signaling pathways, the study aims to identify novel targets for intervention and potential biomarkers for prognosis and treatment response. Furthermore, the project will explore the role of microRNAs in mediating treatment resistance in cancer. Resistance to chemotherapy, targeted therapies, and immunotherapies remains a significant challenge in cancer management. By elucidating how microRNAs influence the development of resistance mechanisms, the research seeks to uncover new avenues for overcoming treatment resistance and improving patient outcomes. Through a comprehensive analysis of the current literature, experimental studies, and bioinformatics approaches, this project will provide valuable insights into the complex interplay between microRNAs and cancer biology. The findings have the potential to inform the development of innovative therapeutic approaches targeting microRNAs or their downstream effectors to enhance treatment efficacy and overcome resistance mechanisms in cancer patients. Overall, this research endeavor holds promise for advancing our understanding of the role of microRNAs in cancer progression and treatment resistance, with the ultimate goal of translating these insights into clinical applications that benefit cancer patients worldwide.