Thesis Abstract

Abstract
Cancer remains a significant health challenge worldwide, with treatment resistance and disease progression posing major obstacles to effective management. In recent years, microRNAs (miRNAs) have emerged as critical regulators in cancer biology, influencing various aspects of tumor development, progression, and response to therapy. This thesis aims to explore the role of miRNAs in cancer progression and treatment resistance, with a focus on understanding their molecular mechanisms and potential therapeutic implications. Chapter One provides an introduction to the research topic, outlining the background of the study, defining the problem statement, objectives, limitations, scope, significance, and structure of the thesis. The chapter also includes a comprehensive definition of key terms relevant to the research. Chapter Two presents a detailed literature review encompassing ten key aspects related to miRNAs in cancer biology, highlighting their involvement in tumor initiation, growth, metastasis, and resistance to conventional therapies. The review also discusses the emerging role of miRNAs as diagnostic and prognostic biomarkers in various cancer types. Chapter Three delves into the research methodology employed in this study, covering eight essential components such as sample collection and processing, miRNA profiling techniques, bioinformatics analysis, cell culture experiments, and in vivo studies. The chapter provides a detailed overview of the research design and methods used to investigate the functional roles of miRNAs in cancer progression and treatment resistance. Chapter Four presents a thorough discussion of the research findings, elucidating the molecular mechanisms through which specific miRNAs modulate key signaling pathways involved in cancer progression and therapy resistance. The chapter also explores the potential of miRNA-based therapeutics in overcoming treatment resistance and enhancing the efficacy of current anticancer strategies. In Chapter Five, the conclusion and summary of the thesis are provided, highlighting the key findings, implications, and future directions for research in the field of miRNAs and cancer biology. The chapter discusses the clinical relevance of miRNAs as therapeutic targets and prognostic markers, emphasizing the importance of further studies to translate these findings into clinical applications. Overall, this thesis contributes to the growing body of knowledge on the role of miRNAs in cancer progression and treatment resistance, providing valuable insights into their potential as novel therapeutic targets for improving cancer outcomes. The research findings underscore the significance of miRNAs in driving tumor aggressiveness and treatment refractoriness, paving the way for the development of innovative precision medicine approaches in cancer management.

Thesis Overview

The project titled "Exploring the Role of MicroRNAs in Cancer Progression and Treatment Resistance" aims to investigate the significance of microRNAs in the context of cancer progression and treatment resistance. MicroRNAs are small non-coding RNA molecules that play crucial regulatory roles in gene expression and have been implicated in various cellular processes, including cancer development and progression. Understanding the specific roles of microRNAs in cancer can provide valuable insights into the underlying mechanisms of tumor growth, metastasis, and resistance to therapy. The research will delve into the molecular mechanisms by which microRNAs influence cancer progression and treatment response. By examining the dysregulation of specific microRNAs in different types of cancer, the study seeks to identify potential biomarkers for early detection, prognosis, and personalized treatment strategies. Additionally, the project will explore the interplay between microRNAs and key signaling pathways involved in cancer development, such as cell proliferation, apoptosis, and metastasis. Moreover, the investigation will address the role of microRNAs in mediating treatment resistance in cancer patients. By elucidating how microRNAs contribute to resistance against chemotherapy, targeted therapies, and immunotherapies, the research aims to uncover novel therapeutic targets and strategies to overcome drug resistance and improve patient outcomes. The project will also consider the potential of microRNAs as therapeutic agents themselves, either as direct targets for intervention or as tools for modulating cancer cell behavior. Overall, this research overview highlights the importance of exploring the role of microRNAs in cancer progression and treatment resistance. By advancing our understanding of the molecular mechanisms underlying these processes, this study has the potential to contribute significantly to the development of more effective diagnostic tools and therapeutic approaches for combating cancer.