Thesis Abstract

Abstract
MicroRNAs (miRNAs) are small non-coding RNAs that play crucial roles in gene expression regulation and have been implicated in various biological processes, including cancer progression. This thesis aims to explore the role of miRNAs in cancer progression and their potential therapeutic implications. The study begins with a comprehensive review of the literature on miRNAs and cancer, highlighting the importance of these small RNAs in tumorigenesis and metastasis. Chapter 1 provides the groundwork for the research project, starting with an introduction to the topic of miRNAs in cancer and their significance in oncology. The background of the study delves into the molecular mechanisms of miRNA function and their dysregulation in cancer. The problem statement identifies the gaps in current knowledge regarding specific miRNAs and their roles in different types of cancer. The objectives of the study are outlined to investigate the specific miRNAs involved in cancer progression and their potential as therapeutic targets. The limitations and scope of the study are discussed, along with the significance of the research in advancing our understanding of cancer biology. The structure of the thesis is presented to guide the reader through the study, and key terms are defined to establish a common understanding of the terminology used. Chapter 2 consists of a detailed literature review that examines the current state of knowledge on miRNAs in cancer. Ten key areas of focus are identified, including the dysregulation of specific miRNAs in different cancer types, the functional roles of miRNAs in cancer progression, and the potential of miRNAs as diagnostic and prognostic biomarkers. Chapter 3 describes the research methodology used to investigate the role of miRNAs in cancer progression. The methodology includes sample collection and processing, miRNA profiling techniques, bioinformatics analysis, and experimental validation of miRNA targets. Eight key components of the methodology are outlined to provide a clear understanding of the research approach. Chapter 4 presents a detailed discussion of the findings obtained from the study. The results of miRNA profiling and functional analyses are discussed in relation to cancer progression and potential therapeutic implications. The role of specific miRNAs in regulating key cancer pathways and their interactions with target genes are explored to uncover novel insights into cancer biology. Chapter 5 concludes the thesis by summarizing the key findings and implications of the research. The potential applications of miRNAs as diagnostic biomarkers and therapeutic targets in cancer are discussed, along with future directions for research in this field. The study contributes to the growing body of knowledge on miRNAs in cancer and highlights the importance of these small RNAs in understanding and treating cancer. Overall, this thesis provides valuable insights into the role of miRNAs in cancer progression and their potential as therapeutic targets, advancing our understanding of cancer biology and opening up new avenues for cancer treatment strategies.

Thesis Overview

The project entitled "Exploring the role of microRNAs in cancer progression and potential therapeutic implications" aims to investigate the intricate involvement of microRNAs in cancer progression and explore their potential as therapeutic targets in the treatment of cancer. This research overview provides an in-depth analysis of the significance and complexity of microRNAs in influencing cancer development and progression, as well as the promising therapeutic strategies that could be derived from understanding these molecular mechanisms. Cancer is a complex and multifaceted disease characterized by uncontrolled cell growth and proliferation, often resulting in the formation of malignant tumors. Emerging evidence suggests that microRNAs, small non-coding RNA molecules, play a crucial role in regulating gene expression and influencing various cellular processes involved in tumorigenesis. Dysregulation of microRNAs has been implicated in the development and progression of various types of cancer, affecting key pathways that control cell proliferation, apoptosis, migration, and invasion. Understanding the specific roles of microRNAs in cancer progression is essential for identifying potential biomarkers for diagnosis, prognosis, and personalized treatment strategies. By elucidating the intricate regulatory networks involving microRNAs and their target genes, researchers can uncover novel therapeutic targets that could be exploited for the development of more effective and targeted cancer therapies. This project aims to explore the diverse functions of microRNAs in different types of cancer, investigate their impact on key signaling pathways driving tumorigenesis, and evaluate their potential as therapeutic targets for cancer treatment. By utilizing advanced molecular biology techniques, bioinformatics analysis, and in vitro and in vivo studies, this research seeks to unravel the complex interplay between microRNAs and cancer progression. The findings from this study have the potential to significantly advance our understanding of the molecular mechanisms underlying cancer development and progression, paving the way for the development of innovative therapeutic interventions that target specific microRNAs or their signaling pathways. Ultimately, this research aims to contribute valuable insights into the potential use of microRNAs as diagnostic biomarkers and therapeutic targets in the fight against cancer, with the ultimate goal of improving patient outcomes and quality of life.