Thesis Abstract

Abstract
Cancer remains a significant global health challenge, with a complex and multifaceted etiology. The study of microRNAs (miRNAs) has emerged as a promising area of research in cancer biology, offering insights into the molecular mechanisms underlying cancer development and progression. This thesis aims to explore the role of miRNAs in cancer, with a specific focus on their involvement in cancer development and progression. Chapter One provides an introduction to the research topic, presenting the background of the study, problem statement, objectives, limitations, scope, significance, structure of the thesis, and definitions of key terms. The literature review in Chapter Two delves into ten key studies that have contributed to our understanding of miRNAs in cancer biology, highlighting the current state of knowledge in the field. Chapter Three outlines the research methodology employed in this study, detailing the research design, data collection methods, sample selection criteria, data analysis techniques, and ethical considerations. The findings of the research are discussed in Chapter Four, providing an in-depth analysis of the role of miRNAs in cancer development and progression based on the study results. The conclusion and summary in Chapter Five offer a synthesis of the key findings, implications of the research, and recommendations for future studies in this area. Overall, this thesis contributes to the growing body of knowledge on the role of miRNAs in cancer biology, shedding light on their potential as diagnostic biomarkers and therapeutic targets in the fight against cancer. Keywords microRNAs, cancer, development, progression, biomarkers, therapeutic targets.

Thesis Overview

The project titled "Exploring the Role of MicroRNAs in Cancer Development and Progression" aims to investigate the intricate involvement of microRNAs in the complex process of cancer development and progression. MicroRNAs, small non-coding RNA molecules, have emerged as key regulators of gene expression and are known to play critical roles in various biological processes, including cancer initiation, growth, metastasis, and response to therapy. Understanding the specific roles and mechanisms of action of microRNAs in cancer pathogenesis is crucial for the development of novel diagnostic and therapeutic strategies. This research overview will delve into the significance of microRNAs in cancer biology, highlighting their potential as diagnostic biomarkers and therapeutic targets. The project will involve a comprehensive review of the current literature on microRNAs in cancer, focusing on their dysregulation in different cancer types and their impact on key cellular processes such as proliferation, apoptosis, and metastasis. The research methodology will include bioinformatics analysis, experimental validation studies, and clinical correlation analyses to elucidate the functional relevance of specific microRNAs in different stages of cancer progression. By integrating computational and experimental approaches, this study aims to identify novel microRNA signatures associated with cancer development and progression, providing insights into the underlying molecular mechanisms and potential therapeutic interventions. The findings of this research are expected to contribute to the growing body of knowledge on the role of microRNAs in cancer and have implications for personalized cancer therapy. By unraveling the intricate network of interactions between microRNAs and target genes in cancer cells, this project seeks to provide new avenues for the development of precision medicine approaches that target specific microRNA pathways for improved cancer management. In conclusion, the project "Exploring the Role of MicroRNAs in Cancer Development and Progression" represents a significant endeavor to advance our understanding of the molecular mechanisms driving cancer pathogenesis. Through a multidisciplinary approach integrating bioinformatics, experimental biology, and clinical research, this study aims to uncover novel insights into the role of microRNAs in cancer biology and pave the way for the development of innovative therapeutic strategies tailored to individual patients based on their microRNA profiles.