Thesis Abstract

Abstract
Cancer continues to be a major global health challenge, with a pressing need for innovative therapeutic approaches. MicroRNAs (miRNAs) have emerged as key regulators of gene expression and have been implicated in various biological processes, including cancer progression. This thesis aims to explore the role of miRNAs in cancer progression and their therapeutic potential. Chapter One provides an introduction to the study, presenting the background of the research, problem statement, objectives, limitations, scope, significance, and the structure of the thesis. The chapter also defines key terms relevant to the study. Chapter Two consists of a comprehensive literature review, encompassing ten key areas related to miRNAs in cancer progression, highlighting the latest research findings and gaps in knowledge. Chapter Three outlines the research methodology, detailing the study design, sample collection methods, data analysis techniques, and ethical considerations. It also discusses the tools and techniques used for miRNA profiling and functional studies. Chapter Four presents an in-depth discussion of the research findings, including the identification of dysregulated miRNAs in various cancer types, their impact on cancer progression, and the potential therapeutic applications of targeting these miRNAs. The chapter also explores the challenges and future directions in miRNA-based cancer therapy. Chapter Five serves as the conclusion and summary of the thesis, summarizing the key findings, discussing their implications, and providing recommendations for future research in this field. Overall, this thesis sheds light on the crucial role of miRNAs in cancer progression and highlights their potential as novel therapeutic targets for the treatment of cancer. By elucidating the intricate mechanisms underlying miRNA dysregulation in cancer, this research contributes to the ongoing efforts to develop more effective and personalized cancer therapies.

Thesis Overview

The project titled "Exploring the Role of MicroRNAs in Cancer Progression and Therapeutic Potential" delves into the intricate relationship between microRNAs and cancer progression, with a specific focus on their therapeutic potential. MicroRNAs are small non-coding RNA molecules that play crucial roles in gene regulation, including the regulation of key processes involved in cancer development and progression. Understanding the specific roles of microRNAs in cancer can provide valuable insights into the underlying mechanisms of tumorigenesis and potentially lead to the development of novel targeted therapies for cancer treatment. The research aims to comprehensively investigate the involvement of microRNAs in driving cancer progression and explore their potential as therapeutic targets. By conducting a detailed literature review, the project will synthesize existing knowledge on the dysregulation of specific microRNAs in various types of cancer and their impact on critical cellular pathways. This review will highlight the importance of microRNAs as key players in cancer biology and emphasize their potential as diagnostic biomarkers and therapeutic targets. Furthermore, the project will employ state-of-the-art research methodologies to analyze the expression profiles of specific microRNAs in cancer cell lines and patient samples. Through experimental approaches such as quantitative real-time PCR and bioinformatics analysis, the study aims to identify dysregulated microRNAs associated with cancer progression and elucidate their functional roles in promoting tumorigenesis. The findings from this research endeavor are expected to provide valuable insights into the complex interplay between microRNAs and cancer progression, shedding light on novel therapeutic strategies that target these small regulatory molecules. By elucidating the mechanisms by which microRNAs contribute to cancer development, the project seeks to contribute to the growing body of knowledge in cancer biology and pave the way for the development of more effective and personalized cancer therapies. Overall, the project "Exploring the Role of MicroRNAs in Cancer Progression and Therapeutic Potential" holds significant promise in advancing our understanding of the molecular mechanisms underlying cancer progression and in identifying innovative approaches for the treatment of various types of cancer. Through a multidisciplinary approach that combines bioinformatics, molecular biology, and clinical research, this project aims to make a meaningful contribution to the field of cancer biology and ultimately improve patient outcomes in the fight against cancer.