Thesis Abstract

Abstract
Cancer is a complex disease characterized by uncontrolled cell growth and proliferation, leading to the formation of malignant tumors. MicroRNAs (miRNAs) have emerged as key regulators of gene expression, playing crucial roles in various cellular processes, including cell proliferation, differentiation, and apoptosis. In recent years, there has been growing interest in understanding the role of miRNAs in cancer development and progression. This thesis aims to explore the intricate relationship between miRNAs and cancer, focusing on their potential as diagnostic markers and therapeutic targets. Chapter One provides an introduction to the topic, highlighting the background of the study, problem statement, objectives, limitations, scope, significance, structure of the thesis, and definitions of key terms. The literature review in Chapter Two delves into ten key studies that have investigated the role of miRNAs in different types of cancer, highlighting their diverse functions and dysregulation in tumorigenesis. Chapter Three outlines the research methodology employed in this study, including the selection of miRNAs of interest, sample collection, RNA extraction, miRNA expression analysis techniques, bioinformatics tools used for data analysis, and statistical methods applied. Chapter Four presents a detailed discussion of the findings, analyzing the dysregulated miRNAs associated with specific cancer types and their potential diagnostic and therapeutic implications. The conclusion in Chapter Five summarizes the key findings of the study, emphasizing the importance of miRNAs as promising biomarkers for cancer detection and as potential targets for novel therapeutic interventions. This research contributes to the growing body of knowledge on the role of miRNAs in cancer development and progression, highlighting their potential clinical utility in improving cancer diagnosis and treatment strategies. Further research in this field is essential to unravel the complex mechanisms underlying miRNA dysregulation in cancer and to translate these findings into clinical practice for better patient outcomes.

Thesis Overview

The project titled "Exploring the role of microRNAs in cancer development and progression" delves into the intricate world of microRNAs and their significant impact on cancer initiation, development, and progression. MicroRNAs are small non-coding RNA molecules that play a crucial role in regulating gene expression at the post-transcriptional level. They have emerged as key players in various biological processes, including cell proliferation, differentiation, and apoptosis, making them attractive targets for cancer research. This research aims to provide a comprehensive understanding of how microRNAs function in the context of cancer development and progression. By exploring the intricate mechanisms through which these molecules influence oncogenic pathways, this study seeks to unravel the complexities of cancer biology and identify potential therapeutic targets for intervention. The project will involve a multifaceted approach that combines bioinformatics analysis, cell culture experiments, and molecular biology techniques to investigate the expression profiles and functional roles of specific microRNAs in different types of cancer. By examining the dysregulation of microRNAs in cancer cells and their impact on key signaling pathways, this research aims to uncover novel insights into the molecular mechanisms driving tumorigenesis. Furthermore, this study will explore the potential diagnostic and prognostic value of microRNAs in cancer management. By identifying specific microRNA signatures associated with different cancer types and disease stages, this research aims to develop non-invasive biomarkers that can aid in early detection, prognosis, and treatment selection for cancer patients. Overall, this project seeks to contribute to the growing body of knowledge on the role of microRNAs in cancer biology and provide valuable insights that may pave the way for the development of innovative therapeutic strategies for combating cancer. Through a comprehensive exploration of the intricate interplay between microRNAs and cancer progression, this research aims to shed light on new avenues for personalized cancer treatment and improve patient outcomes in the fight against this devastating disease.