Thesis Abstract

Abstract
MicroRNAs (miRNAs) are small non-coding RNA molecules that play crucial roles in post-transcriptional gene regulation. In recent years, there has been growing interest in exploring the involvement of miRNAs in cancer progression. This thesis aims to investigate the role of miRNAs in cancer progression, focusing on their mechanisms of action, dysregulation in cancer cells, and potential as diagnostic and therapeutic targets. Chapter One provides an introduction to the study, offering background information on miRNAs, highlighting the problem statement, objectives of the study, limitations, scope, significance, structure of the thesis, and definitions of key terms. The literature review in Chapter Two synthesizes existing knowledge on miRNAs in cancer progression, covering topics such as miRNA biogenesis, functions in cancer development, and potential clinical applications. Chapter Three outlines the research methodology, including the study design, sample collection, miRNA profiling techniques, data analysis methods, and statistical approaches. The findings discussed in Chapter Four present a detailed analysis of the role of specific miRNAs in different types of cancer, their dysregulation patterns, and associations with clinical outcomes. The discussion also explores the potential of miRNAs as biomarkers for cancer diagnosis, prognosis, and therapy. In conclusion, Chapter Five summarizes the key findings of the study, highlighting the significance of miRNAs in cancer progression and their potential impact on clinical practice. This thesis contributes to the growing body of knowledge on the role of miRNAs in cancer, emphasizing their importance as molecular regulators with diagnostic and therapeutic implications. Future research directions are also proposed to further explore the potential of miRNAs in personalized cancer medicine.

Thesis Overview

The project titled "Exploring the Role of MicroRNAs in Cancer Progression" aims to investigate the intricate involvement of microRNAs in the progression of cancer. MicroRNAs are small non-coding RNAs that play crucial roles in regulating gene expression at the post-transcriptional level. In recent years, there has been growing interest in understanding how dysregulation of microRNAs contributes to the development and progression of cancer. The research will delve into the specific microRNAs implicated in different types of cancer and explore their functions in promoting or inhibiting tumor growth, metastasis, and resistance to therapy. By elucidating the molecular mechanisms through which microRNAs influence key cellular processes, such as cell proliferation, apoptosis, and migration, this study aims to provide valuable insights into the complex interplay between microRNAs and cancer progression. Furthermore, the project will investigate the diagnostic and therapeutic potential of targeting microRNAs in cancer treatment. By identifying specific microRNAs as potential biomarkers for cancer detection and prognosis, as well as exploring the use of microRNA-based therapies for personalized cancer treatment, this research seeks to contribute to the advancement of precision medicine in oncology. Overall, this project represents a comprehensive exploration of the role of microRNAs in cancer progression, with the ultimate goal of enhancing our understanding of the molecular mechanisms driving cancer development and identifying novel strategies for more effective cancer diagnosis and treatment.