Thesis Abstract

Abstract
Cancer remains a significant global health challenge, with the need for innovative therapeutic strategies becoming increasingly urgent. MicroRNAs (miRNAs) have emerged as key regulators of gene expression and cellular processes, making them promising targets for cancer therapy. This thesis explores the role of miRNAs in cancer progression and their potential as therapeutic targets. The study begins with a comprehensive review of the literature on miRNAs in cancer, highlighting their diverse functions in tumorigenesis, metastasis, and drug resistance. The research methodology section details the experimental approaches used to investigate the expression profiles and functional roles of specific miRNAs in different cancer types. Through in vitro and in vivo studies, the findings reveal novel insights into the mechanisms by which miRNAs modulate key signaling pathways involved in cancer progression. The discussion of findings delves into the complex interplay between miRNAs and their target genes, shedding light on how dysregulation of miRNA expression contributes to oncogenesis. Furthermore, the study examines the potential of miRNAs as therapeutic targets, discussing the challenges and opportunities in developing miRNA-based therapies for cancer treatment. In conclusion, this thesis underscores the importance of understanding the intricate roles of miRNAs in cancer biology and highlights the potential of miRNA-based approaches for precision medicine in oncology. By elucidating the molecular mechanisms underlying miRNA-mediated regulation of cancer progression, this research paves the way for the development of innovative therapeutic strategies aimed at targeting specific miRNAs for improved cancer treatment outcomes.

Thesis Overview

The project titled "Exploring the Role of MicroRNAs in Cancer Progression and Potential Therapeutic Targets" aims to delve into the intricate world of microRNAs and their significant role in cancer progression, as well as their potential as therapeutic targets. MicroRNAs are small non-coding RNA molecules that play crucial roles in gene regulation, and their dysregulation has been implicated in various diseases, including cancer. In recent years, there has been growing interest in understanding the specific roles of microRNAs in cancer development and progression, with the hope of identifying novel therapeutic strategies. The research will begin with a comprehensive review of the current literature on microRNAs in cancer, exploring the known mechanisms by which microRNAs contribute to cancer progression. This review will provide a solid foundation for the subsequent experimental work, guiding the selection of specific microRNAs to investigate and potential therapeutic targets to explore. The experimental phase of the project will involve the analysis of microRNA expression profiles in different cancer cell lines and patient samples. By utilizing advanced molecular biology techniques such as next-generation sequencing and quantitative PCR, the project aims to identify dysregulated microRNAs that are associated with specific cancer types and stages. Additionally, functional studies will be conducted to elucidate the impact of these dysregulated microRNAs on key cancer-related processes such as cell proliferation, migration, and invasion. Furthermore, the project will explore the therapeutic potential of targeting dysregulated microRNAs in cancer treatment. Through the use of in vitro and in vivo models, the efficacy of microRNA-based therapies, such as synthetic microRNA mimics or inhibitors, will be assessed. The ultimate goal is to identify promising therapeutic targets that can be further developed for clinical applications in cancer treatment. Overall, this research project seeks to deepen our understanding of the role of microRNAs in cancer progression and to explore the therapeutic potential of targeting these molecules. By shedding light on the complex interplay between microRNAs and cancer biology, this study aims to contribute valuable insights to the field of oncology and pave the way for the development of innovative and targeted therapies for cancer patients.