Home / Biochemistry / ANTILIPIDEMIC EFFECT OF WATER (H20) EXTRACT OF DESMODIUM VELUTINUM LEAVES ON ALBINO WISTAR RATS

ANTILIPIDEMIC EFFECT OF WATER (H20) EXTRACT OF DESMODIUM VELUTINUM LEAVES ON ALBINO WISTAR RATS

 

Table Of Contents


Chapter ONE

1.1 Introduction
1.2 Background of study
1.3 Problem Statement
1.4 Objective of study
1.5 Limitation of study
1.6 Scope of study
1.7 Significance of study
1.8 Structure of the research
1.9 Definition of terms

Chapter TWO

2.1 Overview of Antilipidemic effects
2.2 Desmodium Velutinum leaves
2.3 Lipid profile and metabolism
2.4 Previous studies on Antilipidemic effects
2.5 Mechanisms of action
2.6 Animal models in lipid research
2.7 Phytochemical composition of Desmodium Velutinum
2.8 Pharmacological properties of Desmodium Velutinum
2.9 Comparative studies with other antilipidemic agents
2.10 Dosage forms and administration of Desmodium Velutinum

Chapter THREE

3.1 Research design
3.2 Sampling techniques
3.3 Data collection methods
3.4 Data analysis procedures
3.5 Ethical considerations
3.6 Statistical tools used
3.7 Experimental setup
3.8 Variables under study

Chapter FOUR

4.1 Overview of research findings
4.2 Effects of Desmodium Velutinum on lipid profile
4.3 Comparison with standard antilipidemic drugs
4.4 Influence of dosage on antilipidemic effects
4.5 Duration of treatment effects
4.6 Side effects observed
4.7 Possible interactions with other medications
4.8 Future research directions

Chapter FIVE

5.1 Summary of research findings
5.2 Conclusion
5.3 Implications of the study
5.4 Recommendations for practice
5.5 Recommendations for future research

Thesis Abstract

This study evaluated the antilipidemic activity of water extracts from leaves of Desmodium velutinum on albino wistar rats. The phytochemical analysis of the leaf extract showed the presence of tannins, saponins, alkaloids, soluble carbohydrates, flavonoids, reducing sugar, steroids, cyanide and terpenoids. The animals were treated with known drugs (atorvastatin 2ml). There were significantly reductions in HDL 13.00
1.41 mg/dl LDL 1.20
0.14 mg/dl and triglyceride 39.00
0.14 mg/dl, compared with water extract of Desmodium velutinum (0.5ml). when administered was found to significantly reduce lipid plasma which was LDL 1.90
0.00mg/dl, triglyceride 50.00
0.00mg/dl and increase HDL 25.00
0.00 mg/dl which is the good cholesterol. The water extract of Desmodium velutinum leaf can possibly normalize the plasma lipid when compared with the group given atorvastatin. The phytochemicals analysis showed that the association between these complexes and compounds and other constituent play an important role in the biological activity of the leaf. This study suggested that the water extract of D.velutinum leaf posses hypolipidemic as well as antilipidemic effect.

Thesis Overview

Lipid and lipoprotein abnormalities play a major role in the development and progression of coronary artery diseases. Low levels of high density lipoprotein cholesterols have been identified as independent coronary risk factors (Rodrigue et al., 2010). High level of blood cholesterol is responsible for circulatory system disorder. Increase level of low density lipoprotein (LDL) is alarming for cardiovascular diseases and their risk is increased many times (Harman et al., 2011).
In developing countries, the occurrence of heart diseases increases rapidly (Nordestgard et al., 2010). Medical studies show that about 70% of adults over 50 years old suffer atherosclerosis. (Sherien and Azza, 2009). A large number of synthetic hypolipidemic drugs are available in market. Long term use of these drugs cause serious side effects, and are costly.
A medicinal plant is any plant which in one or more of its organ, contains substance that can be used for therapeutic purpose or which is a precursor for synthesis of useful drugs (Sivakumar et al., 2007). Plant contains a large number of bioactive phytochemicals that are responsible for pharmacological action of plants and used for development of drugs. Many
medicinal plants have shown their antilipidemic effect and proved their efficacy in cardiovascular diseases (Nordestgard et al., 2010; Wang, 1999).
One of such plants used very often in the management of the disease by the traditional medicine practitioners of Eastern Nigeria is Desmodium velutium, a perennial plant erect or semi-erect shrub or sub-shrub up to 3m light. It is widely distributed in subtropical Asia and tropical Africa. (Amowi and Azode, 2012).
Extracts of Desmodium velutium are used traditionally in some disease conditions particularly aphrodisiac and headache. Hence, Desomdium velutium may be a source of a pharmacological active agent useful in the treatment of aches, pains and diarrhoea. In Ghana, native doctors mix the root of Desmodium lasincarpum with some hot peppers and use it as enema to cure blood in urine. In Eastern States of Nigeria, the plant locally known as β€œIkeagwuani”. (Onyegbule et al., 2012). In these present studies, I investigated the antilipidemic activity of the water (H2O) extract of Desmodium velutinum Leaves on albino wistar rats.

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