Thesis Abstract

Abstract
MicroRNAs (miRNAs) are small non-coding RNAs that play crucial roles in gene regulation, and their dysregulation has been implicated in various diseases, including cancer. This thesis explores the role of miRNAs in cancer progression and the potential therapeutic implications of targeting these molecules. The study begins with a comprehensive review of the literature on miRNAs in cancer, highlighting their diverse functions in tumor initiation, progression, and metastasis. The research methodology section describes the experimental approaches used to investigate specific miRNAs and their targets in cancer cell lines and animal models. The findings of this study reveal that certain miRNAs act as oncogenes, promoting cancer cell proliferation, invasion, and resistance to therapy, while others function as tumor suppressors, inhibiting key oncogenic pathways. By targeting these miRNAs using various strategies, such as miRNA mimics or inhibitors, it is possible to modulate cancer cell behavior and sensitize tumors to conventional therapies. Moreover, the development of miRNA-based therapeutics, including nanoparticle delivery systems and exosome-mediated transfer, holds promise for personalized cancer treatment. The significance of this research lies in its potential to uncover novel biomarkers for cancer diagnosis and prognosis, as well as identify new therapeutic targets for drug development. By elucidating the intricate regulatory networks controlled by miRNAs in cancer cells, this study contributes to a deeper understanding of tumor biology and the mechanisms driving malignant transformation. The limitations of the study, including the complexity of miRNA-mediated gene regulation and the challenges of translating preclinical findings to clinical applications, are also discussed. In conclusion, this thesis provides valuable insights into the role of miRNAs in cancer progression and highlights the therapeutic potential of targeting these molecules in cancer treatment. By combining cutting-edge molecular biology techniques with bioinformatics analyses, this study advances our knowledge of miRNA function in cancer and paves the way for future research in the field of precision oncology.

Thesis Overview