Studying the Mechanisms of DNA Damage and Repair in Brain Cancer
Table Of Contents
1. Introduction
1.1 Background and significance
1.2 Objectives of the study
2. Brain Cancer: An Overview
2.1 Types and classification of brain tumors
2.2 Molecular characteristics of brain cancer
2.3 DNA damage and repair in cancer development
3. DNA Damage in Brain Cancer
3.1 Sources of DNA damage in brain cells
3.2 Types of DNA lesions in brain cancer
3.3 Factors influencing DNA damage accumulation
4. DNA Repair Mechanisms in Brain Cancer
4.1 Base excision repair (BER)
4.2 Nucleotide excision repair (NER)
4.3 Mismatch repair (MMR)
4.4 Homologous recombination (HR)
4.5 Non-homologous end joining (NHEJ)
5. Impaired DNA Repair in Brain Cancer
5.1 Defects in DNA repair genes
5.2 Altered DNA repair pathway regulation
5.3 Consequences of impaired DNA repair in brain cancer
Thesis Abstract
Brain cancer is a devastating disease characterized by uncontrolled cell growth and invasion in the brain tissue. DNA damage and impaired DNA repair mechanisms have been implicated in the development and progression of brain cancer. This project aims to investigate the mechanisms of DNA damage and repair specifically in brain cancer, with a focus on understanding the molecular pathways involved and their potential as therapeutic targets. Through a combination of experimental techniques, data analysis, and literature review, this study will contribute to a better understanding of the underlying biology of brain cancer and may lead to the development of novel treatment strategies.
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