1. Introduction
  1.1 Background and significance
  1.2 Objectives of the study
2. Literature Review
  2.1 Overview of colorectal cancer
  2.2 Drug metabolism in cancer cells
  2.3 Role of drug-metabolizing enzymes in colorectal cancer
  2.4 Genetic variations and drug response
3. Methodology
  3.1 Cell culture and experimental design
  3.2 Analysis of drug-metabolizing enzymes
  3.3 Metabolic profiling of colorectal cancer cells
  3.4 Genetic analysis of drug metabolism-related genes
4. Results and Discussion
  4.1 Expression and activity of drug-metabolizing enzymes in colorectal cancer cells
  4.2 Metabolic pathways involved in drug metabolism
  4.3 Genetic variations and drug response in colorectal cancer
5. Implications and Future Directions
  5.1 Clinical implications of the findings
  5.2 Limitations and future research directions