1. Introduction
  1.1 Background and significance
  1.2 Objectives of the study
2. Drug metabolism in lung cancer
  2.1 Role of drug-metabolizing enzymes
  2.2 Altered drug metabolism in lung cancer
3. Drug-metabolizing enzymes in lung cancer
  3.1 Cytochrome P450 enzymes
  3.2 UDP-glucuronosyltransferases
  3.3 Glutathione S-transferases
4. Impact of altered drug metabolism on drug efficacy and toxicity
  4.1 Drug response in lung cancer
  4.2 Drug toxicity in lung cancer
5. Experimental methods
  5.1 Cell culture and treatment
  5.2 Expression analysis of drug-metabolizing enzymes
  5.3 Enzyme activity assays