<p>1. Introduction<br> 1.1 Background and rationale<br> 1.2 Objectives of the study<br>2. Blood composition and function<br> 2.1 Overview of blood components<br> 2.2 Role of blood in drug distribution and metabolism<br> 2.3 Biochemical processes involved in drug metabolism in the blood<br>3. Enzymatic pathways in blood drug metabolism<br> 3.1 Overview of blood-specific enzymes<br> 3.2 Expression and activity of enzymes involved in blood drug metabolism<br> 3.3 Impact of enzymatic pathways on drug metabolism in the blood<br>4. Drug transporters in blood<br> 4.1 Overview of drug transporters in blood<br> 4.2 Expression and function of drug transporters in blood<br> 4.3 Role of drug transporters in drug distribution and metabolism in the blood<br>5. Impact of blood biochemistry on drug pharmacokinetics<br> 5.1 Absorption, distribution, metabolism, and excretion (ADME) of drugs in blood<br> 5.2 Influence of blood biochemistry on drug bioavailability and clearance<br> 5.3 Implications for drug efficacy and toxicity<br></p>
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