1. Introduction
  1.1 Background and rationale
  1.2 Objectives of the study
2. Bone structure and function
  2.1 Overview of bone tissue
  2.2 Role of bone in drug distribution and metabolism
  2.3 Biochemical processes involved in drug metabolism in the bone
3. Enzymatic pathways in bone drug metabolism
  3.1 Overview of bone-specific enzymes
  3.2 Expression and activity of enzymes involved in bone drug metabolism
  3.3 Impact of enzymatic pathways on drug metabolism in the bone
4. Drug transporters in bone tissue
  4.1 Overview of drug transporters in bone
  4.2 Expression and function of drug transporters in bone tissue
  4.3 Role of drug transporters in drug distribution and metabolism in the bone
5. Impact of bone metabolism on drug pharmacokinetics
  5.1 Absorption, distribution, metabolism, and excretion (ADME) of drugs in bone tissue
  5.2 Influence of bone metabolism on drug bioavailability and clearance
  5.3 Implications for drug efficacy and toxicity