Investigating the biochemistry of drug metabolism in the adipose tissue
Table Of Contents
1. Introduction
1.1 Background
1.2 Objectives
2. Adipose Tissue: Structure and Function
2.1 White Adipose Tissue (WAT) and Brown Adipose Tissue (BAT)
2.2 Adipose Tissue Distribution and Metabolic Functions
3. Enzymatic Pathways of Drug Metabolism in Adipose Tissue
3.1 Phase I Metabolism: Cytochrome P450 Enzymes
3.2 Phase II Metabolism: Glucuronidation and Sulfation
3.3 Enzyme Expression and Activity in Adipose Tissue
4. Adipose-Specific Factors Influencing Drug Metabolism
4.1 Adipokines and Cytokines
4.2 Adipose Tissue Blood Flow and Drug Distribution
4.3 Adipose Tissue Inflammation and Drug Response
5. Impact of Adipose Tissue Drug Metabolism on Drug Efficacy and Toxicity
5.1 Lipophilic Drug Accumulation in Adipose Tissue
5.2 Drug Release from Adipose Tissue Depots
5.3 Adipose Tissue-Mediated Drug Interactions
Thesis Abstract
Adipose tissue, commonly known as fat, is not only an energy storage site but also plays a crucial role in drug metabolism. This project aims to investigate the biochemistry of drug metabolism in the adipose tissue, including the enzymatic pathways involved, the impact of adipose-specific factors on drug disposition, and the implications for drug efficacy and toxicity. Understanding the adipose tissue's role in drug metabolism can lead to improved drug dosing strategies and personalized medicine approaches.
Thesis Overview
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