Thesis Abstract

This project aims to investigate the biochemistry of drug metabolism in the placenta, which plays a critical role in protecting the developing fetus from harmful substances. The placenta acts as a barrier between the maternal and fetal circulations and is involved in the metabolism and transport of drugs and xenobiotics. Understanding the biochemical processes involved in placental drug metabolism is essential for assessing the safety and efficacy of medications during pregnancy. This project will involve studying the enzymatic pathways and transporters involved in placental drug metabolism, investigating the impact of drug metabolism on fetal development, and exploring the factors that influence placental drug metabolism. The findings from this study will contribute to our understanding of drug safety during pregnancy and may have implications for personalized medicine.

Thesis Overview