Analyzing the role of biochemistry in neurodegenerative diseases
Table Of Contents
1. Introduction
1.1 Background
1.2 Objectives
2. Molecular pathways in neurodegenerative diseases
2.1 Protein aggregation and misfolding
2.2 Mitochondrial dysfunction
2.3 Excitotoxicity and calcium dysregulation
3. Oxidative stress and neurodegeneration
3.1 Reactive oxygen species (ROS) and antioxidant defense
3.2 Lipid peroxidation and protein oxidation
4. Inflammation and neurodegenerative diseases
4.1 Role of microglia and astrocytes
4.2 Neuroinflammatory pathways
5. Biomarkers for neurodegenerative diseases
5.1 Cerebrospinal fluid (CSF) biomarkers
5.2 Blood-based biomarkers
Thesis Abstract
Neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and Huntington's disease, are characterized by the progressive loss of neurons and cognitive decline. The underlying biochemical mechanisms contributing to these diseases are not fully understood. This project aims to analyze the role of biochemistry in neurodegenerative diseases by investigating the molecular pathways, protein misfolding, oxidative stress, and inflammation associated with these conditions. The findings from this study will contribute to a better understanding of the biochemical basis of neurodegenerative diseases and may provide insights for the development of novel therapeutic strategies.
Thesis Overview
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