Investigating the Biochemistry of Antibiotic Resistance
Table Of Contents
<p>1. Introduction<br> 1.1 Background and significance<br> 1.2 Objectives of the study<br>2. Biochemical Mechanisms of Antibiotic Resistance<br> 2.1 Drug efflux and multidrug resistance pumps<br> 2.2 Target modification and antibiotic binding sites<br> 2.3 Enzymatic inactivation and antibiotic degradation<br>3. Genetic and Biochemical Factors in Resistance<br> 3.1 Acquisition and spread of resistance genes<br> 3.2 Horizontal gene transfer and plasmids<br> 3.3 Mutations and selection pressure<br>4. Biochemical Adaptations in Resistant Bacteria<br> 4.1 Metabolic changes and altered pathways<br> 4.2 Biofilm formation and antibiotic tolerance<br> 4.3 Quorum sensing and communication in resistance<br>5. Strategies to Overcome Antibiotic Resistance<br> 5.1 Combination therapy and synergistic effects<br> 5.2 Targeting resistance mechanisms and pathways<br> 5.3 Development of new antibiotics and alternatives<br></p>
Thesis Abstract
<p> This project aims to investigate the biochemistry of antibiotic resistance. Antibiotic resistance is a global health concern, and understanding the underlying biochemical mechanisms is crucial for developing effective strategies to combat resistant bacteria. This project will involve studying the biochemical processes involved in antibiotic resistance, including drug efflux, target modification, and enzymatic inactivation. The focus will be on the genetic and biochemical factors that contribute to resistance, as well as the mechanisms by which bacteria acquire and spread resistance genes. The findings from this research will contribute to the development of new antibiotics and the design of strategies to overcome antibiotic resistance. <br></p>Thesis Overview
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