Development of a Point-of-Care Testing Device for Rapid Diagnosis of Infectious Diseases in Resource-Limited Settings

Thesis Abstract

Abstract
In resource-limited settings, the timely and accurate diagnosis of infectious diseases is crucial for effective disease management and control. This thesis presents the development of a Point-of-Care Testing (POCT) device aimed at providing rapid and reliable diagnosis of infectious diseases in such settings. The device aims to address the challenges associated with traditional diagnostic methods, such as long turnaround times, the need for laboratory infrastructure, and limited access to skilled healthcare personnel. Chapter One provides an introduction to the research topic, highlighting the background of the study, the problem statement, objectives, limitations, scope, significance, structure of the thesis, and definition of terms. The research aims to bridge the gap in diagnostic capabilities in resource-limited settings by developing a portable and user-friendly POCT device that can accurately detect a range of infectious diseases. Chapter Two presents a comprehensive literature review covering ten key areas relevant to the development of POCT devices for infectious disease diagnosis. This includes discussions on existing diagnostic methods, challenges in resource-limited settings, advances in POCT technologies, and the importance of rapid and accurate diagnosis in infectious disease management. Chapter Three outlines the research methodology employed in the development of the POCT device. This chapter covers various aspects such as device design, selection of diagnostic targets, assay development, device prototyping, validation studies, and usability testing. The methodology emphasizes the need for robust and sensitive diagnostic assays that can be easily integrated into a user-friendly and cost-effective device. Chapter Four presents a detailed discussion of the findings from the development and testing of the POCT device. This includes the performance evaluation of the device in detecting infectious diseases, comparison with standard laboratory methods, user feedback, and potential areas for improvement. The chapter also discusses the implications of the findings in the context of disease management in resource-limited settings. Chapter Five offers a conclusion and summary of the project thesis, highlighting the key findings, contributions to the field of medical laboratory science, and recommendations for future research and development. The POCT device shows promise in enhancing diagnostic capabilities in resource-limited settings, offering a convenient and effective tool for rapid diagnosis of infectious diseases. Overall, this thesis contributes to the advancement of POCT technologies for infectious disease diagnosis in resource-limited settings, addressing critical healthcare challenges and improving patient outcomes through timely and accurate diagnosis.