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Synthesis and antimicrobial activity of branched benzoxazinophenothiazines and their derivatives

 

Table Of Contents


Title page – – – – – – – – – – – i
Approval Page- – – – – – – – – – – ii
Certification – – – – – – – – – – – iii
Dedication – – – – – – – – – – – iv
Acknowledgment – – – – – – – – – – v
Abstract – – – – – – – – – – – vi
Table of contents – – – – – – – – – -vii
List of Figures- – – – – – – – – – -viii
List of Abbreviations – – – – – – – – – – x
List of Tables – – – – – – – – – – -xi

Chapter ONE

: INTRODUCTION
1.1 Background of study – – – – – – – – – 1
1.2 Statement of the Problem – – – – – – – – 4
1.3 Objectives of the Study – – – – – – – – 5
1.4 Justification of the Study – – – – – – – – 5

Chapter TWO

: LITERATURE REVIEW
2.0 Linear Phenothiazine – – – – – – – – – 6
2.1 Synthesis of Triazaphenothiazine – – – – – – – 7
2.2 Synthesis of Tetraazaphenothiazine – – – – – – – 9
2.3 Angular Phenothiazine – – – – – – – -10
viii
2.4 Aza Analogue of Angular phenothiazine – – – – – -13
2.5 Linear Phenoxazine – – – – – – – – – 18
2.6 Angular Phenoxazine – – – – – – – – – 19
2.7 Aza- Analogue of Angular Phenoxazine – – – – – -23
2.8 Branched phenothiazine and Phenoxazine Compounds – – – – 27

Chapter THREE

: EXPERIMENTAL
3.0 General Information – – – – – – – – – 35
3.1 6-Chloro-10-nitro-5H-benzo[a]phenoxazin-5-one – – – – – 35
3.2 14- Nitrobenzo[a][1,4]benzoxazino[3,2,-c]phenothiazine – – – -36
3.3 11-Amino-6-Chloro-9-thiol-8,10-diazabenzo[a]phenoxazin-5-one – – – 37
3.4 15-Amino-13-thiol-12,14-diazabenzo[a][1,4]benzoxazino[3,2- c]phenothiazine – 37
3.5 6,8-Dichlorobenzo[a]phenoxazin-5-one – – – – – – 38
3.6 12-Chloro-9-methoxy-8-azabenzo[a][1,4]benzoxazino[3,2-c]phenothiazine – 38
3.7 Antimicrobial Activity – – – – – – – – 39
3.8 Sensitivity testing of compounds – – – – – – – 39
3.9 Minimum inhibitory concentration testing of compounds – – – – 40

Chapter FOUR

: RESULTS AND DISCUSSION
4.1 6-Chloro-10-nitro-5H-benzo[a]phenoxazin-5-one – – – – – 41
4.2 11-Amino-6-Chloro-9-thiol-8,10-diazabenzo[a]phenoxazin-5-one – – -44
4.3 6,8-Dichlorobenzo[a]phenoxazin-5-one – – – – – – 47
4.4 Result of Antimicrobial Sensitivity Test – – – – – – 50
ix
4.5 Minimum inhibitory Concentration Determination – – – – – 51
4.6 Result of Minimum Inhibitory Concentration – – – – – 52

Chapter FIVE


Conclusion – – – – – – – – – – – 53
References – – – – – – – – – – – 54

Thesis Abstract

Thesis Overview

Title page – – – – – – – – – – – i
Approval Page- – – – – – – – – – – ii
Certification – – – – – – – – – – – iii
Dedication – – – – – – – – – – – iv
Acknowledgment – – – – – – – – – – v
Abstract – – – – – – – – – – – vi
Table of contents – – – – – – – – – -vii
List of Figures- – – – – – – – – – -viii
List of Abbreviations – – – – – – – – – – x
List of Tables – – – – – – – – – – -xi
CHAPTER ONE: INTRODUCTION
1.1 Background of study – – – – – – – – – 1
1.2 Statement of the Problem – – – – – – – – 4
1.3 Objectives of the Study – – – – – – – – 5
1.4 Justification of the Study – – – – – – – – 5
CHAPTER TWO: LITERATURE REVIEW
2.0 Linear Phenothiazine – – – – – – – – – 6
2.1 Synthesis of Triazaphenothiazine – – – – – – – 7
2.2 Synthesis of Tetraazaphenothiazine – – – – – – – 9
2.3 Angular Phenothiazine – – – – – – – -10
viii
2.4 Aza Analogue of Angular phenothiazine – – – – – -13
2.5 Linear Phenoxazine – – – – – – – – – 18
2.6 Angular Phenoxazine – – – – – – – – – 19
2.7 Aza- Analogue of Angular Phenoxazine – – – – – -23
2.8 Branched phenothiazine and Phenoxazine Compounds – – – – 27
CHAPTER THREE: EXPERIMENTAL
3.0 General Information – – – – – – – – – 35
3.1 6-Chloro-10-nitro-5H-benzo[a]phenoxazin-5-one – – – – – 35
3.2 14- Nitrobenzo[a][1,4]benzoxazino[3,2,-c]phenothiazine – – – -36
3.3 11-Amino-6-Chloro-9-thiol-8,10-diazabenzo[a]phenoxazin-5-one – – – 37
3.4 15-Amino-13-thiol-12,14-diazabenzo[a][1,4]benzoxazino[3,2- c]phenothiazine – 37
3.5 6,8-Dichlorobenzo[a]phenoxazin-5-one – – – – – – 38
3.6 12-Chloro-9-methoxy-8-azabenzo[a][1,4]benzoxazino[3,2-c]phenothiazine – 38
3.7 Antimicrobial Activity – – – – – – – – 39
3.8 Sensitivity testing of compounds – – – – – – – 39
3.9 Minimum inhibitory concentration testing of compounds – – – – 40
CHAPTER FOUR: RESULTS AND DISCUSSION
4.1 6-Chloro-10-nitro-5H-benzo[a]phenoxazin-5-one – – – – – 41
4.2 11-Amino-6-Chloro-9-thiol-8,10-diazabenzo[a]phenoxazin-5-one – – -44
4.3 6,8-Dichlorobenzo[a]phenoxazin-5-one – – – – – – 47
4.4 Result of Antimicrobial Sensitivity Test – – – – – – 50
ix
4.5 Minimum inhibitory Concentration Determination – – – – – 51
4.6 Result of Minimum Inhibitory Concentration – – – – – 52
CHAPTER FIVE
Conclusion – – – – – – – – – – – 53
References – – – – – – – – – – – 54

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