Synthesis and antimicrobial activity of branched benzoxazinophenothiazines and their derivatives

• Title page – – – – – – – – – – – i Approval Page- – – – – – – – – – – ii Certification – – – – – – – – – – – iii Dedication – – – – – – – – – – – iv Acknowledgment – – – – – – – – – – v Abstract – – – – – – – – – – – vi Table of contents – – – – – – – – – -vii List of Figures- – – – – – – – – – -viii List of Abbreviations – – – – – – – – – – x List of Tables – – – – – – – – – – -xi

Chapter ONE

INTRODUCTION

• 1.1Background of study – – – – – – – – – 1
• 1.2Statement of the Problem – – – – – – – – 4
• 1.3Objectives of the Study – – – – – – – – 5
• 1.4Justification of the Study – – – – – – – – 5

Chapter TWO

LITERATURE REVIEW

• 2.0Linear Phenothiazine – – – – – – – – – 6
• 2.1Synthesis of Triazaphenothiazine – – – – – – – 7
• 2.2Synthesis of Tetraazaphenothiazine – – – – – – – 9
• 2.3Angular Phenothiazine – – – – – – – -10 viii
• 2.4Aza Analogue of Angular phenothiazine – – – – – -13
• 2.5Linear Phenoxazine – – – – – – – – – 18
• 2.6Angular Phenoxazine – – – – – – – – – 19
• 2.7Aza- Analogue of Angular Phenoxazine – – – – – -23
• 2.8Branched phenothiazine and Phenoxazine Compounds – – – – 27

Chapter THREE

RESEARCH METHODOLOGY

• EXPERIMENTAL
• 3.0General Information – – – – – – – – – 35
• 3.16-Chloro-10-nitro-5H-benzo[a]phenoxazin-5-one – – – – – 35
• 3.214- Nitrobenzo[a][1,4]benzoxazino[3,2,-c]phenothiazine – – – -36
• 3.311-Amino-6-Chloro-9-thiol-8,10-diazabenzo[a]phenoxazin-5-one – – – 37
• 3.415-Amino-13-thiol-12,14-diazabenzo[a][1,4]benzoxazino[3,2- c]phenothiazine – 37
• 3.56,8-Dichlorobenzo[a]phenoxazin-5-one – – – – – – 38
• 3.612-Chloro-9-methoxy-8-azabenzo[a][1,4]benzoxazino[3,2-c]phenothiazine – 38
• 3.7Antimicrobial Activity – – – – – – – – 39
• 3.8Sensitivity testing of compounds – – – – – – – 39
• 3.9Minimum inhibitory concentration testing of compounds – – – – 40

Chapter FOUR

DATA PRESENTATION AND ANALYSIS

• RESULTS AND DISCUSSION
• 4.16-Chloro-10-nitro-5H-benzo[a]phenoxazin-5-one – – – – – 41
• 4.211-Amino-6-Chloro-9-thiol-8,10-diazabenzo[a]phenoxazin-5-one – – -44
• 4.36,8-Dichlorobenzo[a]phenoxazin-5-one – – – – – – 47
• 4.4Result of Antimicrobial Sensitivity Test – – – – – – 50 ix
• 4.5Minimum inhibitory Concentration Determination – – – – – 51
• 4.6Result of Minimum Inhibitory Concentration – – – – – 52

Chapter FIVE

SUMMARY, CONCLUSION AND RECOMMENDATIONS

• – – – – – – – – – – – 53 References – – – – – – – – – – – 54