Assessment of the Efficacy of Nano-hydroxyapatite in Remineralization of Enamel Lesions: A Randomized Clinical Trial

Thesis Abstract

Abstract
Enamel lesions resulting from demineralization pose a significant concern in dental health. The use of nano-hydroxyapatite has emerged as a promising approach for remineralization therapy. This thesis presents the findings from a randomized clinical trial that aimed to assess the efficacy of nano-hydroxyapatite in remineralizing enamel lesions. The study involved a sample of participants with varying degrees of enamel lesions, who were randomly assigned to either a treatment group receiving nano-hydroxyapatite or a control group receiving a placebo. Over a specified period, various clinical parameters and imaging techniques were used to evaluate the extent of remineralization in the enamel lesions. The introduction chapter sets the stage for the study, providing a background to enamel lesions, the problem statement, research objectives, limitations, scope, significance, and defining key terms. The literature review chapter critically examines existing studies on nano-hydroxyapatite and remineralization techniques, providing a comprehensive understanding of the theoretical framework underlying the study. In the research methodology chapter, the study design, participant selection criteria, intervention protocols, outcome measures, data collection methods, and statistical analysis plan are elaborated upon. The discussion of findings chapter presents a detailed analysis of the results obtained from the clinical trial, discussing the efficacy of nano-hydroxyapatite in promoting remineralization and comparing outcomes between the treatment and control groups. The conclusion and summary chapter highlight the key findings of the study, discussing the implications for dental practice and potential areas for future research. Overall, the results suggest that nano-hydroxyapatite shows promise as an effective agent for remineralizing enamel lesions, with significant improvements observed in the treatment group compared to the control group. This study contributes valuable insights to the field of dental research, emphasizing the potential of nano-hydroxyapatite in enhancing enamel remineralization and supporting the development of novel therapeutic strategies for managing enamel lesions.