The effect of the ethanolic extract of anchomanes difformis (blume) on liver functions of adult wistar rats..
Table Of Contents
Chapter ONE
INTRODUCTION
- 1.1Introduction
- 1.2Background of Study
- 1.3Problem Statement
- 1.4Objective of Study
- 1.5Limitation of Study
- 1.6Scope of Study
- 1.7Significance of Study
- 1.8Structure of the Research
- 1.9Definition of Terms
Chapter TWO
LITERATURE REVIEW
- 2.1Review of Literature on Liver Functions
- 2.2Previous Studies on Ethanol Extracts
- 2.3Health Benefits of Anchomanes Difformis
- 2.4Liver Function Tests
- 2.5Mechanisms of Liver Damage
- 2.6Role of Antioxidants in Liver Health
- 2.7Toxicity Studies on Anchomanes Difformis
- 2.8Effects of Plant Extracts on Liver Functions
- 2.9Ethnopharmacological Uses of Anchomanes Difformis
- 2.10Comparative Studies on Liver Protection
Chapter THREE
RESEARCH METHODOLOGY
- 3.1Research Methodology Overview
- 3.2Research Design and Approach
- 3.3Sampling Techniques
- 3.4Data Collection Methods
- 3.5Data Analysis Procedures
- 3.6Ethical Considerations
- 3.7Instrumentation and Materials
- 3.8Statistical Analysis Plan
Chapter FOUR
DATA PRESENTATION AND ANALYSIS
- 4.1Presentation of Research Findings
- 4.2Liver Function Test Results
- 4.3Effects of Anchomanes Difformis Extract on Liver Enzymes
- 4.4Histopathological Findings
- 4.5Comparative Analysis with Control Group
- 4.6Discussion on Antioxidant Properties
- 4.7Interpretation of Toxicity Studies
- 4.8Implications for Liver Health
Chapter FIVE
SUMMARY, CONCLUSION AND RECOMMENDATIONS
- 5.1Conclusion and Summary
- 5.2Summary of Findings
- 5.3Implications for Future Research
- 5.4Recommendations for Practice
- 5.5Contributions to Knowledge
Thesis Abstract
This research was carried out to determine the effect of administration of Achomanes Difformis (blume) on liver functions in adult wistar rat, in which 20 adult wistar rats were purchased at the institute of advanced medical research and training (IMRAT), UCH, Ibadan. The rats were grouped into 4 in which there is a control group in which the rats were placed on normal diet and water. Other groups (A, B and C) were administered 300mg/kg/b.wt, 500mg/kg/b.wt and 700mg/kg/b.wt respectively. The herb was administered for duration of 14 days. Their cages were cleaned every day maintain proper hygiene. The rats were sacrificed immediately after two weeks of drug administration. From the result obtained, the administration of Anchomanes difformis has a hepatotoxic effect. It showed that there was an insignificant increase (p>0.05) in the level of AST, ALT and ALP, and an insignificant decrease (p>0.05) in the level of Total and Direct Bilirubin in the plasma at different dosage rate of the herb, when compared to the control group. The result demonstrates that the ingestion of Anchomanes difformis has a hepatotoxic effect in adult wistar rat.
Thesis Overview
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