The effect of the ethanolic extract of anchomanes difformis (blume) on liver functions of adult wistar rats
Table Of Contents
Chapter ONE
INTRODUCTION
- 1.1Introduction
- 1.2Background of Study
- 1.3Problem Statement
- 1.4Objective of Study
- 1.5Limitation of Study
- 1.6Scope of Study
- 1.7Significance of Study
- 1.8Structure of the Research
- 1.9Definition of Terms
Chapter TWO
LITERATURE REVIEW
- 2.1Overview of Liver Functions
- 2.2Previous Studies on Anchomanes Difformis (Blume)
- 2.3Liver Diseases and Their Implications
- 2.4Bioactive Compounds in Anchomanes Difformis (Blume)
- 2.5Pharmacological Actions of Ethanolic Extracts
- 2.6Animal Models for Liver Function Studies
- 2.7Effects of Ethanolic Extracts on Liver Functions
- 2.8Mechanisms of Action of Anchomanes Difformis (Blume)
- 2.9Dosage and Administration
- 2.10Comparative Studies with Other Substances
Chapter THREE
RESEARCH METHODOLOGY
- 3.1Research Design
- 3.2Sampling Techniques
- 3.3Data Collection Methods
- 3.4Experimental Procedures
- 3.5Statistical Analysis Plan
- 3.6Ethical Considerations
- 3.7Validity and Reliability
- 3.8Data Interpretation Methods
Chapter FOUR
DATA PRESENTATION AND ANALYSIS
- 4.1Overview of Experimental Results
- 4.2Effects of Anchomanes Difformis (Blume) Extract on Liver Enzymes
- 4.3Histopathological Findings on Liver Tissues
- 4.4Comparative Analysis with Control Group
- 4.5Discussion on Biochemical Parameters
- 4.6Interpretation of Results
- 4.7Correlation with Previous Studies
- 4.8Implications for Liver Function Research
Chapter FIVE
SUMMARY, CONCLUSION AND RECOMMENDATIONS
- 5.1Summary of Findings
- 5.2Conclusion
- 5.3Recommendations for Future Research
- 5.4Practical Applications
- 5.5Contribution to Scientific Knowledge
Thesis Abstract
This research was carried out to determine the effect of administration of Achomanes Difformis (blume) on liver functions in adult wistar rat, in which 20 adult wistar rats were purchased at the institute of advanced medical research and training (IMRAT), UCH, Ibadan. The rats were grouped into 4 in which there is a control group in which the rats were placed on normal diet and water. Other groups (A, B and C) were administered 300mg/kg/b.wt, 500mg/kg/b.wt and 700mg/kg/b.wt respectively. The herb was administered for duration of 14 days. Their cages were cleaned every day maintain proper hygiene. The rats were sacrificed immediately after two weeks of drug administration. From the result obtained, the administration of Anchomanes difformis has a hepatotoxic effect. It showed that there was an insignificant increase (p>0.05) in the level of AST, ALT and ALP, and an insignificant decrease (p>0.05) in the level of Total and Direct Bilirubin in the plasma at different dosage rate of the herb, when compared to the control group. The result demonstrates that the ingestion of Anchomanes difformis has a hepatotoxic effect in adult wistar rat.
Thesis Overview
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