Estrogen receptor β and breast cancer | Blazingprojects Postgraduate Thesis
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Estrogen receptor β and breast cancer

 

Table Of Contents


Chapter ONE

INTRODUCTION

  • 1.1Introduction
  • 1.2Background of Study
  • 1.3Problem Statement
  • 1.4Objective of Study
  • 1.5Limitation of Study
  • 1.6Scope of Study
  • 1.7Significance of Study
  • 1.8Structure of the Research
  • 1.9Definition of Terms

Chapter TWO

LITERATURE REVIEW

  • 2.1Overview of Breast Cancer
  • 2.2Estrogen Receptor β in Breast Cancer
  • 2.3Role of Hormones in Breast Cancer Development
  • 2.4Genetic Factors in Breast Cancer
  • 2.5Current Treatment Options for Breast Cancer
  • 2.6Studies on Estrogen Receptor β and Breast Cancer
  • 2.7Impact of Estrogen Receptor β on Breast Cancer Prognosis
  • 2.8Emerging Therapies Targeting Estrogen Receptor β
  • 2.9Challenges in Targeting Estrogen Receptor β
  • 2.10Future Directions in Estrogen Receptor β Research

Chapter THREE

RESEARCH METHODOLOGY

  • 3.1Research Design and Methodology
  • 3.2Selection of Study Participants
  • 3.3Data Collection Methods
  • 3.4Data Analysis Techniques
  • 3.5Ethical Considerations
  • 3.6Pilot Study Description
  • 3.7Sampling Techniques
  • 3.8Research Instruments Used

Chapter FOUR

DATA PRESENTATION AND ANALYSIS

  • 4.1Presentation of Research Findings
  • 4.2Analysis of Research Findings
  • 4.3Interpretation of Results
  • 4.4Comparison with Existing Literature
  • 4.5Discussion of Key Findings
  • 4.6Implications of Findings
  • 4.7Recommendations for Practice
  • 4.8Suggestions for Future Research

Chapter FIVE

SUMMARY, CONCLUSION AND RECOMMENDATIONS

  • 5.1Summary of Research
  • 5.2Conclusions Drawn from the Study
  • 5.3Contribution to Existing Knowledge
  • 5.4Practical Implications
  • 5.5Limitations of the Study
  • 5.6Recommendations for Further Research
  • 5.7Conclusion and Final Remarks

Thesis Abstract

Despite the primary role of estrogen receptor α (ERα) in mediating the effects of estrogen in malignant breast and as therapeutic target, the development of endocrine-resistant and metastatic phenotypes indicates the complexity of the mechanisms that regulate hormone signaling in the disease. The discovery of ERβ and its functional characterization has improved our understanding about the mechanism of estrogen receptor action, the regulation of estrogen signaling in breast tumors, and their response to therapy. The progressive decline of ERβ in pro-invasive lesions and invasive tumors points toward a role as suppressor of both tumorigenesis and progression in breast cancer. The antiproliferative and anti-invasive effects of the receptor and its agonists in preclinical models of breast cancer support these roles and delineate the mechanisms of action. The association of ERβ with clinical outcome proposes the potential use of the receptor as prognostic marker and its agonists in chemoprevention and therapeutic strategies for resistant and metastatic disease.

Thesis Overview

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