EPIDEMIOLOGICAL STUDIES AND MOLECULAR CHARACTERISATION OF DERMATOPHYTES AMONG ALMAJIRAI IN MAKARFI LOCAL GOVERNMENT AREA OF KADUNA STATE | Blazingprojects Postgraduate Thesis
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EPIDEMIOLOGICAL STUDIES AND MOLECULAR CHARACTERISATION OF DERMATOPHYTES AMONG ALMAJIRAI IN MAKARFI LOCAL GOVERNMENT AREA OF KADUNA STATE

 

Table Of Contents


Chapter ONE

INTRODUCTION

  • 1.1Introduction
  • 1.2Background of Study
  • 1.3Problem Statement
  • 1.4Objective of Study
  • 1.5Limitation of Study
  • 1.6Scope of Study
  • 1.7Significance of Study
  • 1.8Structure of the Research
  • 1.9Definition of Terms

Chapter TWO

LITERATURE REVIEW

  • 2.1Review of Epidemiological Studies
  • 2.2Overview of Dermatophytes
  • 2.3Molecular Characterization Techniques
  • 2.4Dermatophytes in Almajirai Communities
  • 2.5Factors Influencing Dermatophyte Infections
  • 2.6Epidemiological Trends of Dermatophytes
  • 2.7Molecular Typing Methods
  • 2.8Impact of Dermatophytes on Public Health
  • 2.9Management of Dermatophyte Infections
  • 2.10Future Directions in Dermatophyte Research

Chapter THREE

RESEARCH METHODOLOGY

  • 3.1Research Methodology Overview
  • 3.2Study Design and Sampling Techniques
  • 3.3Data Collection Methods
  • 3.4Laboratory Procedures for Molecular Characterization
  • 3.5Data Analysis Techniques
  • 3.6Ethical Considerations
  • 3.7Quality Control Measures
  • 3.8Statistical Analysis Plan

Chapter FOUR

DATA PRESENTATION AND ANALYSIS

  • 4.1Demographic Characteristics of Almajirai Participants
  • 4.2Prevalence of Dermatophyte Infections
  • 4.3Molecular Identification of Dermatophyte Species
  • 4.4Factors Associated with Dermatophyte Infections
  • 4.5Comparison of Molecular Typing Methods
  • 4.6Public Health Implications
  • 4.7Management Strategies for Dermatophyte Infections
  • 4.8Discussion of Research Findings

Chapter FIVE

SUMMARY, CONCLUSION AND RECOMMENDATIONS

  • 5.1Summary of Findings
  • 5.2Conclusions
  • 5.3Implications for Public Health
  • 5.4Recommendations for Future Research
  • 5.5Practical Applications of Study Results

Thesis Abstract

ABSTRACT

This study is undertaken to measure the variation of terrestrial gamma radiation and the

activity concentrations of U-238, Th-232 and K-40 in soil of Northern part of Zamfara State (Nigeria), and assess the potential health hazards associated with the exposures to the natural radiation in the area with respect to geological formations. Inspector AlertTM Nuclear Radiation Monitor and HPGe gamma ray spectrometer were used for TGRD and laboratory analyses respectively. The measured TGRD rates ranged from 20.00 to 61.43 nGy/h, with mean value of 31.99 nGy/h. The mean (range) activity concentrations of U-238, Th-232 and K-40 in the soil samples were 19.43 ± 2.23 (8.82 ± 0.95 to 44.22 ± 5.78) Bq/kg, 23.26 ± 8.43 (11.02 ± 1.03 to 43.96 ± 2.15) Bq/kg and 268.62 ± 39.03 (57.45 ± 2.88 to 527.36 ± 12.38) Bq/kg respectively. These results were compared with the world average values for specific activities (i.e. 33, 45 and 420 Bq/kg) for U-238, Th-232 and K-40 respectively, and were found to be less than the worldwide average. The highest TGRD rate and activity concentrations of U-238, Th-232 and K-40 were recorded in an area underlain by Older Granite formation, which are enriched with high contents of radioactive materials. The radiological hazards to the public in the studied area was assessed by estimating mean values of radium equivalent activity, external hazard index, and activity utilization index for the soil samples were found to be 71.674± 7.099 Bq/kg, 0.1936± 0.0192, and 0.4688± 0.0448 respectively.In addition, the mean values of absorbed gamma dose rates, annual outdoors effective dose rates, and excess lifetime cancer risk for both TGRD rate measurements and spectrometric analyses were found to be 31.99 nGy/h, 0.0393 mSv/y and 137.6x10-6, and 33.467



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