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Effects of ethanol leaves extract of jatropha tanjorensis on renal function of male albino wistar rats

 

Table Of Contents


Chapter ONE

INTRODUCTION

  • 1.1Introduction
  • 1.2Background of Study
  • 1.3Problem Statement
  • 1.4Objective of Study
  • 1.5Limitation of Study
  • 1.6Scope of Study
  • 1.7Significance of Study
  • 1.8Structure of the Research
  • 1.9Definition of Terms

Chapter TWO

LITERATURE REVIEW

  • 2.1Overview of Ethanol Leaves Extract
  • 2.2Jatropha Tanjorensis Plant
  • 2.3Renal Function
  • 2.4Effects of Ethanol Extract on Renal Function
  • 2.5Previous Studies on Ethanol Extracts
  • 2.6Pharmacological Properties of Jatropha Tanjorensis
  • 2.7Toxicological Effects of Ethanol Extract
  • 2.8Benefits of Ethanol Extract
  • 2.9Comparison with Other Plant Extracts
  • 2.10Future Research Directions

Chapter THREE

RESEARCH METHODOLOGY

  • 3.1Research Methodology Overview
  • 3.2Research Design
  • 3.3Sampling Techniques
  • 3.4Data Collection Methods
  • 3.5Ethical Considerations
  • 3.6Data Analysis Procedures
  • 3.7Reliability and Validity
  • 3.8Limitations of the Methodology

Chapter FOUR

DATA PRESENTATION AND ANALYSIS

  • 4.1Analysis of Research Findings
  • 4.2Effects of Ethanol Extract on Renal Function
  • 4.3Comparison of Results with Hypotheses
  • 4.4Variability in Results
  • 4.5Discussion on Unexpected Findings
  • 4.6Implications of Findings
  • 4.7Recommendations for Future Research
  • 4.8Practical Applications of Research

Chapter FIVE

SUMMARY, CONCLUSION AND RECOMMENDATIONS

  • 5.1Summary of Findings
  • 5.2Conclusion
  • 5.3Implications for the Field
  • 5.4Contribution to Knowledge
  • 5.5Recommendations for Further Study

Thesis Abstract

This study is aimed at investigating effects of ethanol leaves extract of Jatropha tanjorensis on renal function of male albino wistar rats. Twenty (20) male albino wistar rats were randomly divided into four (4) groups of five (5) rats each. Group 1 served as the control and animals in Group 2, Group 3 and Group 4 were administered 100mg, 250mg and 500mg of the leaves extract per kg body weight respectively for 14 days. The parameters determined were urea, bilirubin (direct and total) and creatinine. Through the study carried out on the effect of Jatropha tanjorensis leaves extract on the renal function of albino wistar rats, it was observed that the treatment groups (II, III, and IV) when administered higher doses showed significant and non-significant (P<0.05) decrease in urea, direct and total bilirubin levels when compared to the control group 1. It was also observed that groups II, III and IV showed a non-significant (P<0.05) increase in creatinine levels when compared to the control group. From these results, it can be established that the leaves extract of Jatropha tanjorensis have no direct effect on renal function and therefore may not be a great cause for concern. This study is aimed at investigating effects of ethanol leaves extract of Jatropha tanjorensis on renal function of male albino wistar rats. Twenty (20) male albino wistar rats were randomly divided into four (4) groups of five (5) rats each. Group 1 served as the control and animals in Group 2, Group 3 and Group 4 were administered 100mg, 250mg and 500mg of the leaves extract per kg body weight respectively for 14 days. The parameters determined were urea, bilirubin (direct and total) and creatinine. Through the study carried out on the effect of Jatropha tanjorensis leaves extract on the renal function of albino wistar rats, it was observed that the treatment groups (II, III, and IV) when administered higher doses showed significant and non-significant (P<0.05) decrease in urea, direct and total bilirubin levels when compared to the control group 1. It was also observed that groups II, III and IV showed a non-significant (P<0.05) increase in creatinine levels when compared to the control group. From these results, it can be established that the leaves extract of Jatropha tanjorensis have no direct effect on renal function and therefore may not be a great cause for concern.

Thesis Overview

<p> </p><p><strong>INTRODUCTION</strong></p><p><strong>1.2 &nbsp;</strong><strong>BACKGROUND OF THE STUDY</strong></p><p><em>Jatropha tanjorensis</em>&nbsp;commonly called “hospital-too-far” or ïyana-ipaja” (Yoruba), “ugu-oyibo” (Igbo) belongs to the family Euphorbiceae and is widely grown in Southern Nigeria (Sofowora., 1993). In Southern Nigeria, it is called “Catholic vegetable” or “Reverend father’s vegetable”, possibly because it is grown in the premises of the Catholic churches as ornamentals. The plant has been used locally as a source of edible leaves vegetable and as a medicinal plant for a number of years (Iwalewa <em>et al.,</em>&nbsp;2005).</p><p>The leaves extract has hypoglycemic and antioxidant properties that makes it a popular remedy for the treatment for diabetic, malaria and hypertension in this region. It was reported that administration of <em>Jatropha tanjorensis </em>leaves powder to rabbits resulted in improvement in hematological indices which revealed an enhancement of bone marrow function (Orhue <em>et al.,</em>&nbsp;2008).</p> <br><p></p>

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