Effect of ethanolic root extract of jathropha tanjorensis on kidney function of female albino wistar rats | Blazingprojects Postgraduate Thesis
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Effect of ethanolic root extract of jathropha tanjorensis on kidney function of female albino wistar rats

 

Table Of Contents


Chapter ONE

INTRODUCTION

  • 1.1Introduction
  • 1.2Background of Study
  • 1.3Problem Statement
  • 1.4Objective of Study
  • 1.5Limitation of Study
  • 1.6Scope of Study
  • 1.7Significance of Study
  • 1.8Structure of the Research
  • 1.9Definition of Terms

Chapter TWO

LITERATURE REVIEW

  • 2.1Overview of Literature Review
  • 2.2Historical Perspectives
  • 2.3Theoretical Framework
  • 2.4Previous Studies on Similar Topics
  • 2.5Current Trends and Developments
  • 2.6Gaps Identified in Existing Literature
  • 2.7Conceptual Framework
  • 2.8Methodological Approaches in Previous Studies
  • 2.9Key Findings from Literature Review
  • 2.10Summary of Literature Review

Chapter THREE

RESEARCH METHODOLOGY

  • 3.1Research Methodology Overview
  • 3.2Research Design and Approach
  • 3.3Sampling Methods
  • 3.4Data Collection Techniques
  • 3.5Data Analysis Methods
  • 3.6Ethical Considerations
  • 3.7Instrumentation Used
  • 3.8Validity and Reliability

Chapter FOUR

DATA PRESENTATION AND ANALYSIS

  • 4.1Overview of Findings
  • 4.2Presentation of Data
  • 4.3Analysis of Results
  • 4.4Comparison with Hypotheses
  • 4.5Discussion of Findings
  • 4.6Implications of Results
  • 4.7Recommendations for Future Research
  • 4.8Limitations of the Study

Chapter FIVE

SUMMARY, CONCLUSION AND RECOMMENDATIONS

  • 5.1Summary of Research
  • 5.2Conclusion
  • 5.3Contributions to the Field
  • 5.4Practical Implications
  • 5.5Recommendations for Practice
  • 5.6Recommendations for Further Research
  • 5.7Reflection on the Research Process
  • 5.8Conclusion Statement

Thesis Abstract

Jatropha tanjorensis has been consumed as a leafy vegetable and as a medicinal plant in Nigeria has shown hematological, antimalarial, antimicrobial, hypoglyceamic, hypolipidemic and antihypertensive   activities. This study was designed to investigate the effect of ethanol root extract of jatropha tanjorensis on the kidney function of albino Wistar rat. Twenty rats (20) adult female adults, the animals were divided into five groups. Group I served as control and was administered water and normal rat feed, group 2 was administered 100mg/kgbwt of extract, group 3 was administered 250mg/kgbwt of extract and finally group 4 was administered 500mg/kgbwt of extract. The administration lasted for 14 days and the experimental animals were sacrificed and blood samples collected. The urea, creatinine, total bilirubin and direct bilirubin level were assayed for and it was observed that the group   II,III and IV showed significant decrease in urea, total bilirubin and direct bilirubin concentrations group II,III and IV also showed siginificant increase in creatinine level. From the results, it has been established that jatropha tanjorensis possess kidney protective properties.

Keywords Creatinine, Direct bilirubin, Jatropha Tanjorensis, Total bilirubin and


Thesis Overview

<p> </p><p><strong>INTRODUCTION</strong></p><p><strong>1.0 &nbsp; &nbsp; &nbsp; Background of the Study &nbsp; &nbsp;</strong></p><p>&nbsp; An increasing reliance on the use of medicinal plants in the industrialized societies has been traced to the extraction and development of many drugs and chemotherapeutics from these plants as well as from traditionally used herbal remedies (Tapsell <em>et al</em>., 2006). A large and increasing number of patients use medicinal herbs or seek the advice of their physician regarding their use. Without doubts, the benefits derived from using medicine obtained from plants are that they are relatively safer than synthetic alternative by offering profound therapeutic benefits and more affordable treatment (Stepp, 2004).</p><p>&nbsp; <em>Jatropha tanjorensis</em>&nbsp;belongs to the family Euphorbiaceae and it shows intermediacy in phenotypic characters between <em>J. gossypifolia</em>&nbsp;and <em>J. curcas</em>&nbsp;(Prabakaran and Sujatha, 1999). It is commonly called hospital too far, Catholic vegetable, Iyana-ipaja, lapalapa (Iwalewa <em>et al</em>., 2005).</p><p>&nbsp; In Nigeria, the leaf of <em>J. tanjorensis</em>&nbsp;has been used locally, consumed as a vegetable and it is popular as a natural remedy against diabetes in this region (Olayiwola <em>et al.</em>, 2004). Recent claims have it that the plant is no longer safe for use and that it could be tox</p> <br><p></p>

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