The Role of MicroRNAs in Cancer Development and Progression: A Biochemical Perspective

Thesis Abstract

Abstract
Cancer is a complex and devastating disease that continues to be a major health concern worldwide. Understanding the underlying mechanisms driving cancer development and progression is crucial for the development of effective diagnostic tools and therapeutic strategies. MicroRNAs (miRNAs) have emerged as key players in cancer biology, exerting regulatory roles in various cellular processes. This thesis investigates the role of miRNAs in cancer development and progression from a biochemical perspective. The introduction provides a background to cancer and miRNA biology, highlighting the importance of studying miRNAs in cancer research. The problem statement identifies the gaps in current knowledge regarding the specific mechanisms by which miRNAs influence cancer development and progression. The objectives of this study are to elucidate the involvement of miRNAs in cancer, identify specific miRNAs associated with different cancer types, and explore the potential of miRNAs as diagnostic or therapeutic targets. The limitations of this study include the complexity of cancer as a multifactorial disease and the challenges associated with studying miRNAs in clinical settings. The scope of the study focuses on analyzing existing literature on miRNAs in cancer, conducting in vitro and in vivo experiments to investigate specific miRNAs, and exploring potential clinical applications of miRNA-based therapies. The significance of this study lies in its potential to contribute to the understanding of cancer biology and provide insights into the development of novel diagnostic and therapeutic approaches. The structure of the thesis includes a detailed review of relevant literature in Chapter Two, a comprehensive methodology for miRNA analysis in cancer research in Chapter Three, a discussion of the findings in Chapter Four, and a conclusion summarizing the key outcomes of the study in Chapter Five. Overall, this thesis aims to advance the current knowledge of the role of miRNAs in cancer development and progression, with the ultimate goal of improving cancer diagnosis, prognosis, and treatment strategies. By shedding light on the intricate interplay between miRNAs and cancer biology, this study contributes to the ongoing efforts to combat cancer and improve patient outcomes.