THE EFFECT OF WATER EXTRACT OF COLA NITIDA POD ON LIPOPROTEIN CONCENTRATIONS OF ALBINO WISTAR RATS | Blazingprojects Postgraduate Thesis
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THE EFFECT OF WATER EXTRACT OF COLA NITIDA POD ON LIPOPROTEIN CONCENTRATIONS OF ALBINO WISTAR RATS

 

Table Of Contents


Chapter ONE

INTRODUCTION

  • 1.1Introduction
  • 1.2Background of Study
  • 1.3Problem Statement
  • 1.4Objective of Study
  • 1.5Limitation of Study
  • 1.6Scope of Study
  • 1.7Significance of Study
  • 1.8Structure of the Research
  • 1.9Definition of Terms

Chapter TWO

LITERATURE REVIEW

  • 2.1Overview of Lipoproteins
  • 2.2Cola Nitida and its Properties
  • 2.3Lipoprotein Metabolism
  • 2.4Effects of Natural Extracts on Lipoprotein Concentrations
  • 2.5Previous Studies on Cola Nitida Extracts
  • 2.6Mechanisms of Lipoprotein Regulation
  • 2.7Lipoprotein Disorders and Health Implications
  • 2.8Lipoprotein Analysis Methods
  • 2.9Lipoprotein Concentration Measurement Techniques
  • 2.10Summary of Literature Review

Chapter THREE

RESEARCH METHODOLOGY

  • 3.1Research Methodology Overview
  • 3.2Study Design
  • 3.3Sampling Techniques
  • 3.4Data Collection Methods
  • 3.5Experimental Protocols
  • 3.6Statistical Analysis Plan
  • 3.7Ethical Considerations
  • 3.8Quality Control Measures

Chapter FOUR

DATA PRESENTATION AND ANALYSIS

  • 4.1Data Analysis and Interpretation
  • 4.2Lipoprotein Concentrations in Control Group
  • 4.3Lipoprotein Concentrations in Experimental Group
  • 4.4Comparison of Lipoprotein Levels
  • 4.5Statistical Significance of Results
  • 4.6Discussion on Findings
  • 4.7Impact of Cola Nitida Extract on Lipoproteins
  • 4.8Factors Influencing Lipoprotein Concentrations

Chapter FIVE

SUMMARY, CONCLUSION AND RECOMMENDATIONS

  • 5.1Conclusion
  • 5.2Summary of Research Findings
  • 5.3Implications of Study
  • 5.4Recommendations for Future Research
  • 5.5Final Remarks

Thesis Abstract

Cola nitida has been in use in the eastern parts of Nigeria for the management of certain ailments and as an aphrodisiac in the management of some sexual dysfunctions. However the effects of this extract in some health parameters in human objects have not been reported. This work, then, was aimed at investigating the effect of water extracts of kola pods on lipoprotein concentrations on albino wistar rats.Rats were used in this study and they were divided into several groups and fed with a high calorie food (cow’s brain) so as to increase the blood lipoprotein concentration in the rat models. The effect of the water extracts of the sample used was compared with a known drug and the results statistically compared to ascertain the effect of the water extract on the rat models.The results of this work indicate that water extracts of cola nitida pods can be used in the management of mild lipoprotein dysfunctions thus substantiating the reasons for its use in sexual erectile functions.

Thesis Overview

1.1 INTRODUCTION
Cola Nitida has been used in folk medicine as an aphrodisiac, an appetite suppressant, to treat morning sickness, migraine headache, and indigestion (Esimone et al., 2007). It has also been applied directly to the skin to treat wounds and inflammation (Newall et al., 1996)on the teeth and gums. There has also been speculations as to its use in the treatment of peptic ulcer, however, in Nigeria there is no record of the incidence of peptic ulcer.According to Esimone (2007), cola nitida tree is native to West Africa. Cola nuts are obtained from cola trees. Cola nitida belongs to the genus cola and family tiliaceae. They are commonly used to counteract hunger and thirst; in some cases it is used to control vomiting in pregnant woman and also as a principal stimulant to keep awake and withstand fatigue by students, drivers, and other menial workers.
Lipoproteins are found in the liver and cells. The liver is the largest organ inside the body. The liver is dark reddish-brown and consists of two main lobes. There are over 300 billion specialized cells in the liver that are connected by a well organized system of “bile” ducts and blood vessels called the biliary system.

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