The effect of the ethanolic extract of anchomanes difformis (blume) on liver functions of adult wistar rats. | Blazingprojects Postgraduate Thesis
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The effect of the ethanolic extract of anchomanes difformis (blume) on liver functions of adult wistar rats.

 

Table Of Contents


Chapter ONE

INTRODUCTION

  • 1.1Introduction
  • 1.2Background of Study
  • 1.3Problem Statement
  • 1.4Objective of Study
  • 1.5Limitation of Study
  • 1.6Scope of Study
  • 1.7Significance of Study
  • 1.8Structure of the Research
  • 1.9Definition of Terms

Chapter TWO

LITERATURE REVIEW

  • 2.1Review of Ethanol's Effects on Liver Functions
  • 2.2Review of Anchomanes Difformis (Blume)
  • 2.3Liver Function Tests
  • 2.4Previous Studies on Liver Function
  • 2.5Mechanism of Liver Damage
  • 2.6Role of Antioxidants in Liver Health
  • 2.7Impact of Herbal Extracts on Liver Functions
  • 2.8Ethanol-Induced Liver Damage
  • 2.9Anchomanes Difformis (Blume) Extracts in Experimental Studies
  • 2.10Comparative Analysis of Liver Function Studies

Chapter THREE

RESEARCH METHODOLOGY

  • 3.1Research Methodology Overview
  • 3.2Study Design and Rationale
  • 3.3Sampling Techniques
  • 3.4Data Collection Methods
  • 3.5Data Analysis Procedures
  • 3.6Ethical Considerations
  • 3.7Instrumentation Used
  • 3.8Statistical Analysis Techniques

Chapter FOUR

DATA PRESENTATION AND ANALYSIS

  • 4.1Overview of Research Findings
  • 4.2Effects of Ethanolic Extract of Anchomanes Difformis (Blume) on Liver Functions
  • 4.3Comparative Analysis of Liver Function Parameters
  • 4.4Statistical Analysis Results
  • 4.5Discussion on the Impact of Herbal Extract on Liver Health
  • 4.6Interpretation of Findings
  • 4.7Implications of Research Findings
  • 4.8Recommendations for Future Studies

Chapter FIVE

SUMMARY, CONCLUSION AND RECOMMENDATIONS

  • 5.1Conclusion and Summary of Findings
  • 5.2Recap of Research Objectives
  • 5.3Contribution to Knowledge
  • 5.4Practical Implications
  • 5.5Limitations of the Study
  • 5.6Suggestions for Further Research

Thesis Abstract

This research was carried out to determine the effect of administration of Achomanes Difformis (blume) on liver functions in adult wistar rat, in which 20 adult wistar rats were purchased at the institute of advanced medical research and training (IMRAT), UCH, Ibadan. The rats were grouped into 4 in which there is a control group in which the rats were placed on normal diet and water. Other groups (A, B and C) were administered 300mg/kg/b.wt, 500mg/kg/b.wt and 700mg/kg/b.wt respectively. The herb was administered for duration of 14 days. Their cages were cleaned every day maintain proper hygiene. The rats were sacrificed immediately after two weeks of drug administration. From the result obtained, the administration of Anchomanes difformis has a hepatotoxic effect. It showed that there was an insignificant increase (p>0.05) in the level of AST, ALT and ALP, and an insignificant decrease (p>0.05) in the level of Total and Direct Bilirubin in the plasma at different dosage rate of the herb, when compared to the control group. The result demonstrates that the ingestion of Anchomanes difformis has a hepatotoxic effect in adult wistar rat.



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