THE EFFECT OF PTEROCARPUS MILDBRAEDII SEED ON PLASMA HDL CHOLESTEROL OF ALBINO RAT | Blazingprojects Postgraduate Thesis
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THE EFFECT OF PTEROCARPUS MILDBRAEDII SEED ON PLASMA HDL CHOLESTEROL OF ALBINO RAT

 

Table Of Contents


Chapter ONE

INTRODUCTION

  • 1.1Introduction
  • 1.2Background of Study
  • 1.3Problem Statement
  • 1.4Objective of Study
  • 1.5Limitation of Study
  • 1.6Scope of Study
  • 1.7Significance of Study
  • 1.8Structure of the Research
  • 1.9Definition of Terms

Chapter TWO

LITERATURE REVIEW

  • 2.1Overview of Literature Review
  • 2.2Historical Perspective
  • 2.3Theoretical Framework
  • 2.4Studies on Pterocarpus Mildbraedii Seed
  • 2.5Effects of Pterocarpus Mildbraedii Seed on Cholesterol
  • 2.6Biochemical Composition of Pterocarpus Mildbraedii Seed
  • 2.7Biological Activities of Pterocarpus Mildbraedii Seed
  • 2.8Pharmacological Properties
  • 2.9Mechanism of Action
  • 2.10Gaps in Existing Literature

Chapter THREE

RESEARCH METHODOLOGY

  • 3.1Research Methodology Overview
  • 3.2Research Design
  • 3.3Sampling Techniques
  • 3.4Data Collection Methods
  • 3.5Data Analysis Techniques
  • 3.6Ethical Considerations
  • 3.7Validity and Reliability
  • 3.8Research Limitations

Chapter FOUR

DATA PRESENTATION AND ANALYSIS

  • 4.1Overview of Findings
  • 4.2Effect of Pterocarpus Mildbraedii Seed on Plasma HDL Cholesterol
  • 4.3Comparison with Control Groups
  • 4.4Variation in Results Across Studies
  • 4.5Factors Influencing Results
  • 4.6Discussion on Mechanisms of Action
  • 4.7Implications of Findings
  • 4.8Recommendations for Future Research

Chapter FIVE

SUMMARY, CONCLUSION AND RECOMMENDATIONS

  • 5.1Conclusion and Summary
  • 5.2Recap of Key Findings
  • 5.3Contributions to Knowledge
  • 5.4Practical Implications
  • 5.5Suggestions for Further Research

Thesis Abstract

This work was carried out to investigate the effects of pterocarpus mildbraedii seed on the HDL- level of albino rats. High density lipoprotein(HDL) is a fraction of cholesterol, which helps to transport cholesterol from peripheral of cell to the liver. High density lipoprotein is carried out to investigate cardiovascular diseases.Fresh oha seed (pterocarpus mildbraedii seed) was collected from Amokwe in udi local government Area Enugu state. They were dried at room temperature for about a month in an open laboratory space, ground into coarse form and weighed on an electrical weighing balance. 3% tween-80 was prepared by dissolving 3% tween -80 in 97ml of distilled water. The grounded pterocarpus mildbraedii was dissolved in the 3% tween-80.A total of sixteen wistar albino rats used for this analysis. The rats were divided into 4(four) groups. Group 1 contained 4 rats and received 0.5 each of 3% tween-80. Group 2 contain 5 rats and were administered with 1400mg/kg b.w of pterocarpus mildbraedii solution Group 3 contain 3 rats and were administered with 2600mg/kg. b.w of pterocarpus mildbraedii solution. Group 4 contain 4 rats and were administered with 500mg/kg. b.w. of Edmark MRT complex.

Thesis Overview

INTRODUCTION1.0 Pterocarpus mildbraedii are trees with edible parts successfully budded, pterocarpus species (P. Soyauxii and P. mildbraedii are reported to have different patterns of leaf flush, one spontaneous and the other intermittent making the first suitable for commercial production and the second the home production (Okafor 1978). Pterocarpus mildbraedii being the major case study both the vegetable and the seeds.
The vegetable is majorly used in our various home for cooking. Pterocarpus mildbraedii (Oha seed) are not consumed by the people from the eastern part of Nigeria. So it cannot be majorly stated the content of this oha seed.The demand for vegetable oils as a result of diminishing source of oils and fats creates the needs for new sources as well as exploiting sources that are currently unexploited in order to supplement the existing ones (Minzangi et al. 2011).As industrialists continues to rely mostly on the popular vegetable oil like coconut oil, soybeans oil, groundnut oil, palm oil etc. for the preparation and production of their various products.Plant lipids also possess nutritive value and have an impact on human nutrition and the world economy. More than three quarters of the edible and industrial oils marketed annually are derived from seed and fruit triglycerol (Schimid & Ohlrogge, 2002). Seeds have nutritive and calorific value which makes them necessary in diets. They are good sources of edible oils and fats. The amount of energy provide by 1g of fat and oil when fully digested is more than twice as many joules of protein and carbohydrate do. Fats makes meals more satisfying, enrich its flavor and delay the onset of hunger (Odoemelan, 2005). Unfortunately, insufficient availability of animal protein and the costliness of available plant protein sources have also increased the need for research on revealing lesser known under-utilized legumes and oil seeds of nutritive value (Schimid & Ohlrogge, 2002).

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