The effect of n-hexane extract of kola nitida bark on liver function test of albino wistar rats fed with high fat
Table Of Contents
Chapter ONE
INTRODUCTION
- 1.1Introduction
- 1.2Background of Study
- 1.3Problem Statement
- 1.4Objective of Study
- 1.5Limitation of Study
- 1.6Scope of Study
- 1.7Significance of Study
- 1.8Structure of the Research
- 1.9Definition of Terms
Chapter TWO
LITERATURE REVIEW
- 2.1Overview of Liver Function
- 2.2High Fat Diet and Liver Function
- 2.3Kola Nitida Bark and its Components
- 2.4Effects of N-Hexane Extracts on Liver Function
- 2.5Previous Studies on Liver Function Tests
- 2.6Mechanisms of Liver Function Tests
- 2.7Role of Liver Enzymes in Liver Function
- 2.8Impact of High-Fat Diet on Liver Enzymes
- 2.9Effects of Kola Nitida Bark on Liver Function
- 2.10Summary of Literature Review
Chapter THREE
RESEARCH METHODOLOGY
- 3.1Research Methodology Overview
- 3.2Research Design
- 3.3Sampling Techniques
- 3.4Data Collection Methods
- 3.5Data Analysis Procedures
- 3.6Ethical Considerations
- 3.7Validity and Reliability Measures
- 3.8Statistical Tools Used
Chapter FOUR
DATA PRESENTATION AND ANALYSIS
- 4.1Overview of Research Findings
- 4.2Effects of N-Hexane Extract on Liver Enzymes
- 4.3Comparison with High-Fat Diet Results
- 4.4Impact of Kola Nitida Bark on Liver Function
- 4.5Statistical Analysis of Data
- 4.6Discussion on the Results
- 4.7Implications of Findings
- 4.8Recommendations for Future Research
Chapter FIVE
SUMMARY, CONCLUSION AND RECOMMENDATIONS
- 5.1Summary of Research
- 5.2Conclusion
- 5.3Contributions to Knowledge
- 5.4Practical Implications
- 5.5Limitations of the Study
- 5.6Recommendations for Practice
- 5.7Recommendations for Further Research
- 5.8Conclusion Remarks
Thesis Abstract
Kola bark extract have been widely used in tradition medicine for thousand of year, it improves liver functions and provides protection against high fat fed metabolic rats. Present investigations were carried out on the hepatoprotective role of Kola bark extract meal treatment to high fat fed wistar rat. Healthy adult male wistar rats were divided into four groups Group I rats were fed a standard Laboratory diet (groups match) (20g/rat/day), Group II rats were fed a high-fat diet alone (3.6g/rat/day), Group III rats were fed with combined mixture of 70% of high-fat diet with 30% Kola bark meal (9.8g/rat /day), Group/ V rats were fed with high fat diet and was administered with Lipitor (Atovastatin) (10mg/rat/day) . The rats were sacrificed at the end of the experiment (two weeks) period. The high fat fed rat substantially elevated its serum and liver tissue AST, ALT, ALP, bilirubin with decreased in total protein levels. Where as the levels of all parameters significantly restored towards normalization by the kola bark husk meal treatment. The results obtained suggest that the Kola bark meal have potent hepatoprotective action on high fat fed rats. A companion of the performance in both Kola bark meal and Lipitor treatment on high fat fed rat in respect of hepatoprotective role is clearly indicator that the Kola bark meal treatment was more and related to the result of Lipitor as well as to the normal level.
Thesis Overview
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