Studying the mechanisms of DNA damage and repair in cancer
Table Of Contents
- 1.Introduction                                      
- 1.1Background
- 1.2Objectives
- 2.DNA damage and genomic instability in cancer
- 2.1Types of DNA damage
- 2.2Sources of DNA damage in cancer
- 2.3Impact of DNA damage on genomic integrity
- 3.DNA repair pathways in cancer
- 3.1Base excision repair (BER)
- 3.2Nucleotide excision repair (NER)
- 3.3Mismatch repair (MMR)
- 3.4Homologous recombination (HR)
- 3.5Non-homologous end joining (NHEJ)
- 4.Interplay between DNA repair and cancer progression
- 4.1DNA repair gene mutations in cancer
- 4.2DNA repair and resistance to therapy
- 4.3DNA repair as a therapeutic target
- 5.Emerging strategies for targeting DNA repair in cancer
- 5.1PARP inhibitors
- 5.2DNA repair gene targeting
- 5.3Combination therapies involving DNA repair inhibitors
Thesis Abstract
DNA damage is a common occurrence in cells, and if left unrepaired, it can lead to genomic instability and the development of cancer. Understanding the mechanisms of DNA damage and repair in cancer is crucial for the development of targeted therapies and personalized medicine approaches. This project aims to study the mechanisms of DNA damage and repair in cancer by investigating the role of DNA repair pathways, the impact of DNA damage on genomic integrity, and the interplay between DNA repair and cancer progression. Additionally, the project will explore the potential of targeting DNA repair pathways as a therapeutic strategy for cancer treatment. The findings from this study will contribute to a better understanding of the biochemistry underlying DNA damage and repair in cancer and may have implications for the development of novel cancer therapies.
Thesis Overview
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