PHYTOCHEMICAL ANALYSIS AND THE ANTI-INFLAMMATORY ACTIVITIES OF DICHLOROMETHANE FRACTION OF METHHANOL EXTRACT OF CRATEVA ADANSONII | Blazingprojects Postgraduate Thesis
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PHYTOCHEMICAL ANALYSIS AND THE ANTI-INFLAMMATORY ACTIVITIES OF DICHLOROMETHANE FRACTION OF METHHANOL EXTRACT OF CRATEVA ADANSONII

 

Table Of Contents


Chapter ONE

INTRODUCTION

  • 1.1Introduction
  • 1.2Background of study
  • 1.3Problem Statement
  • 1.4Objective of study
  • 1.5Limitation of study
  • 1.6Scope of study
  • 1.7Significance of study
  • 1.8Structure of the research
  • 1.9Definition of terms

Chapter TWO

LITERATURE REVIEW

  • 2.1Overview of Phytochemical Analysis
  • 2.2Importance of Phytochemicals in Medicine
  • 2.3Anti-inflammatory Activities of Plant Extracts
  • 2.4Crateva Adansonii: A Brief Overview
  • 2.5Previous Studies on Dichloromethane Fractions
  • 2.6Methodologies for Phytochemical Analysis
  • 2.7Techniques for Anti-inflammatory Activity Assessment
  • 2.8Role of Solvents in Extracting Phytochemicals
  • 2.9Factors Affecting Phytochemical Composition
  • 2.10Mechanisms of Anti-inflammatory Actions

Chapter THREE

RESEARCH METHODOLOGY

  • 3.1Research Methodology Overview
  • 3.2Selection of Research Design
  • 3.3Sampling Techniques
  • 3.4Data Collection Methods
  • 3.5Phytochemical Analysis Procedures
  • 3.6Anti-inflammatory Activity Assays
  • 3.7Statistical Analysis Techniques
  • 3.8Ethical Considerations in Research

Chapter FOUR

DATA PRESENTATION AND ANALYSIS

  • 4.1Analysis of Phytochemical Composition
  • 4.2Evaluation of Anti-inflammatory Properties
  • 4.3Comparison with Other Plant Extracts
  • 4.4Correlation between Phytochemicals and Activities
  • 4.5Impact of Extraction Methods on Results
  • 4.6Discussion on Variability in Phytochemical Content
  • 4.7Interpretation of Statistical Findings
  • 4.8Implications for Future Research

Chapter FIVE

SUMMARY, CONCLUSION AND RECOMMENDATIONS

  • 5.1Summary of Findings
  • 5.2Conclusion and Recommendations
  • 5.3Contributions to Knowledge
  • 5.4Practical Applications of the Study
  • 5.5Areas for Further Research

Thesis Abstract

Inflammation is a complex biological response of vascular tissue to harmful stimuli such as pathogen, damage cells or irritants (Ryan & Majno, 1983). The urgency generated by increased rate of stroke, atherosclerosis attribute due to prolonged use of cyclooxygenase-1 and Cyclooxygenase- 2 inhibitors have accelerated anti-inflammatory drug research over the last decade while synthetic pharmaceutical agents continued to dominate research (Ryan & Majno, 1983). Attention increasingly has been directed to natural products. These are often more affordable and available and sometimes are perceived as more effective than conventional anti- inflammatory drugs.Anti-inflammation was carried out using 12 rats which was divided into three groups of 4 rats each. Group 1 and 2 served as the negative and positive control respectively. Group 3 received 25mg/kg b.w. of the dichloromethane fraction of methanol extract of Crateva adansonii showed significance anti-inflammatory activity when compared with the standard difference used.



Thesis Overview

<p> </p><p>Inflammation is one of body’s natural ways of protecting itself. It is also an essential reaction of the body to infection. Too little of an inflammatory response, and the body is unable to repel microbial invasions or heal injuries. Too much of an inflammatory response, and the immune system begins attacking the body’s own organs eventually leading to chronic disease (Sears, 2000). Anti-Inflammatory refers to the property of a substance or treatment that reduces inflammation. There are obvious clinical markers of inflammation which include pain, redness, fever, swelling and loss of function (Pai et al. 2004). However if inflammation is allowed to continue unchecked it may results in neurodegenerative disease or cancer (Pai et al. 2004). A variety of safe and effective anti-inflammatory agents are available including non-steroidal anti-inflammatory drugs, corticosteroids.</p><p></p><br> <br><p></p>

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